NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model.
NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model.
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NMDA 拮抗剂在体外模型中区分癫痫发生和癫痫发作表达。
DOI：
10.1126/science.2569762
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Wilson,WA
中科院分区：
文献类型：
--
作者：
Stasheff,SF;Anderson,WW;Clark,S;Wilson,WA
在海马切片癫痫发作的电图模型中，N-甲基-D-天冬氨酸（NMDA）拮抗剂2-氨基-5-磷酸戊酸和5-甲基-10，11-二氢-5H-二苯并（a，d）环庚烯-5，10-亚胺马来酸盐（MK-801）都可以预防癫痫发作的进行性发展，但不能阻止先前诱导的癫痫发作。因此，一个依赖于NMDA受体-离子载体复合物的过程建立了一个持久的、易惊厥的状态;此后癫痫发作依赖于非NMDA受体-离子载体机制。这表明癫痫发生和癫痫发作表达之间以及抗癫痫和抗惊厥药物之间存在重要区别。
In an electrographic model of seizures in the hippocampal slice, both of the N-methyl-D-aspartate (NMDA) antagonists 2-amino-5-phosphonovaleric acid and 5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine maleate (MK-801) prevented the progressive development of seizures but did not block previously induced seizures. Thus, a process dependent on the NMDA receptor-ionophore complex establishes a long-lasting, seizure-prone state; thereafter the seizures depend on non-NMDA receptor-ionophore mechanisms. This suggests that there is an important distinction between epileptogenesis and seizure expression and between antiepileptogenic and anticonvulsant pharmacological agents.