Effects of porcine pancreastatin on postprandial pancreatic exocrine secretion and endocrine functions in the conscious rat.
Effects of porcine pancreastatin on postprandial pancreatic exocrine secretion and endocrine functions in the conscious rat.
复制标题
猪胰酶对清醒大鼠餐后胰腺外分泌和内分泌功能的影响。
作者：
Miyasaka,K;Funakoshi,A;Nakamura,R;Kitani,K;Shimizu,F;Tatemoto,K
本文观察了新发现的多肽胰抑素对慢性胆汁、胰腺和胃瘘清醒大鼠餐后胰腺外分泌和内分泌功能的抑制作用。100和200pmol/kg/h的胰抑素显著抑制膳食刺激的胰液和蛋白质的分泌，但不呈剂量依赖性地抑制碳酸氢盐的分泌。静脉注射100pmol/kg/h和200pmoL/kg/h的胰抑素后，血浆胰抑素浓度(Mean±SE)分别增加到133.5±15.9和209.8±14.5pM。然而，相同剂量的胰抑素未能抑制餐后胰岛素和胃泌素的释放，也不影响血糖水平。提示胰岛抑素可能是一种抑制餐后胰腺外分泌的物质。然而，本研究中使用的剂量可能还不够高，不足以影响内分泌功能。
The inhibitory effect of a newly discovered polypeptide, pancreastatin, on postprandial pancreatic exocrine secretions and endocrine functions was examined in the conscious rat with a chronic external bile, pancreatic and gastric fistula. The infusion of 100 and 200 pmol/kg/h of pancreastatin significantly inhibited meal-stimulated pancreatic secretion of fluid and protein but not bicarbonate in a dose-dependent manner. The infusion of 100 and 200 pmol/kg/h of pancreastatin increased plasma pancreastatin concentrations (mean ± SE) up to 133.5 ± 15.9 and 209.8 ± 14.5 pM, respectively. However, the same doses of pancreastatin failed to inhibit postprandial insulin and gastrin releases and did not affect blood glucose levels. It is suggested that pancreastatin may be an inhibitor of postprandial pancreatic exocrine secretion. However, the doses used in the present study may not have been high enough to affect endocrine functions.