A novel improved procedure for the synthesis of oxazoles
A novel improved procedure for the synthesis of oxazoles
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DOI：
10.1016/0040-4020(96)00552-2
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发表时间：
1996-07-22
期刊：
影响因子：
2.1
通讯作者：
Ye, XL
中科院分区：
文献类型：
--
作者：
Huang, W;Pei, J;Ye, XL
本文提出了一种新的、改进的、简便的恶唑类化合物的合成方法。以BF_3/Et_2O为催化剂，在沸腾的二甲苯中，用乙酰胺代替乙酸铵与苯甲酸苯甲酰甲酯反应。根据这一新的合成路线，九个恶唑化合物容易地制备为单一的产品，在合理的高产率。根据实验结果，提出了该反应的可能机理。版权所有（C）1996 Elsevier Science Ltd
In the present work a novel improved and convenient procedure for the synthesis of oxazoles has been developed. Acetamide, instead of ammonium acetate, was used to react with phenacyl benzoates in boiling xylene in the presence of BF3/Et(2)O as the catalyst. According to this new synthetic route, nine oxazole compounds were readily prepared as single products in reasonably high yields. On the basis of the experimental results, a plausible mechanism of this reaction is proposed. Copyright (C) 1996 Elsevier Science Ltd