Reproductive history in relation to breast cancer risk among Hispanic and non-Hispanic white women
Reproductive history in relation to breast cancer risk among Hispanic and non-Hispanic white women
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DOI：
10.1007/s10552-007-9098-1
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发表时间：
2008-05-01
影响因子：
2.3
通讯作者：
Slattery, Martha L.
中科院分区：
文献类型：
--
作者：
Sweeney, Carol;Baumgartner, Kathy B.;Slattery, Martha L.
目的评估美国西南部拉美裔（HISP）女性乳腺癌的生殖史危险因素，该人群乳腺癌发病率比非拉美裔白人（NHW）低约33%。（796例病例，919例对照）和NHW结果19.3%的HISP妇女报告了5次或5次以上的分娩，患乳腺癌的风险降低，与一胎或二胎相比，调整优势比（OR）为0.70（95%置信区间（CI）：0.50，0.98）。HISP的乳腺癌风险随着首次生育年龄的增加而增加，p趋势= 0.008。产次和第一胎年龄的相关性对ER阳性肿瘤是特异的。5年内生育的HISP妇女患乳腺癌的危险性高于16-25年生育的妇女，OR值为2.62（95%CI：1.44，4.78）;生育年限的趋势强于非健康工作者，p交互作用= 0.05。结论HISP中生育史对乳腺癌危险性的影响与非健康工作者相似。生殖风险因素的流行率差异可以解释HISP与NHWs相比乳腺癌发病率估计低6.6%的原因。
Objective To evaluate reproductive history risk factors in breast cancer among Hispanic (HISP) women in the U.S. southwest, a population with approximately 33% lower breast cancer incidence than non-Hispanic whites (NHW).Methods Population-based case-control study of HISP (796 cases, 919 controls) and NHW (1,525 cases, 1,596 controls) women.Results 19.3% of HISP women reported five or more births and had a reduced risk of breast cancer, adjusted odds ratio (OR) 0.70 (95% confidence interval (CI): 0.50, 0.98) compared to those with one or two births. Breast cancer risk for HISP increased with older age at first birth, p trend = 0.008. Parity and age at first birth associations were specific to ER positive tumors. HISP women who had given birth within five years had higher breast cancer risk than women with 16-25 years since a birth, OR 2.62 (95% CI: 1.44, 4.78); the trend with years since last birth was stronger than for NHWs, p interaction = 0.05.Conclusions Reproductive history influences on breast cancer risk among HISP were similar to associations reported for NHWs. Differences in the prevalence of reproductive risk factors would explain an estimated 6.6% lower breast cancer incidence for HISP compared to NHWs.