Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease.
Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease.
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DOI：
10.1038/ng.3268
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发表时间：
2015-06
期刊：
影响因子：
30.8
通讯作者：
de Balcker, Paul I. W.
中科院分区：
文献类型：
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作者：
Gutierrez-Achury, Javier;Zhernakova, Alexandra;Pulit, Sara L.;Trynka, Gosia;Hunt, Karen A.;Romanos, Jihane;Raychaudhuri, Soumya;van Heel, David A.;Wijmenga, Cisca;de Balcker, Paul I. W.
尽管膳食麸质是触发因素，但乳糜泻风险受到主要组织相容性复合体（MHC）区域遗传变异的强烈影响。我们对MHC关联信号进行了精细映射，以确定独立于HLA-DQ等位基因的其他风险因素，并观察到五种新的关联，占遗传风险的18%。加上57个已知的非MHC基因座，遗传变异现在可以解释高达48%的乳糜泻遗传性。
Although dietary gluten is the trigger, celiac disease risk is strongly influenced by genetic variation in the major histocompatibility complex (MHC) region. We fine-mapped the MHC association signal to identify additional risk factors independent of the HLA-DQ alleles and observed five novel associations that account for 18% of the genetic risk. Together with the 57 known non-MHC loci, genetic variation can now explain up to 48% of celiac disease heritability.
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影响因子：
30.8
作者：
Westra, Harm-Jan;Peters, Marjolein J.;Esko, Tonu;Yaghootkar, Hanieh;Schurmann, Claudia;Kettunen, Johannes;Christiansen, Mark W.;Fairfax, Benjamin P.;Schramm, Katharina;Powell, Joseph E.;Zhernakova, Alexandra;Zhernakova, Daria V.;Veldink, Jan H.;Van den Berg, Leonard H.;Karjalainen, Juha;Withoff, Sebo;Uitterlinden, Andre G.;Hofman, Albert;Rivadeneira, Fernando;'t Hoen, Peter A. C.;Reinmaa, Eva;Fischer, Krista;Nelis, Mari;Milani, Lili;Melzer, David;Ferrucci, Luigi;Singleton, Andrew B.;Hernandez, Dena G.;Nalls, Michael A.;Homuth, Georg;Nauck, Matthias;Radke, Doerte;Voelker, Uwe;Perola, Markus;Salomaa, Veikko;Brody, Jennifer;Suchy-Dicey, Astrid;Gharib, Sina A.;Enquobahrie, Daniel A.;Lumley, Thomas;Montgomery, Grant W.;Makino, Seiko;Prokisch, Holger;Herder, Christian;Roden, Michael;Grallert, Harald;Meitinger, Thomas;Strauch, Konstantin;Li, Yang;Jansen, Ritsert C.;Visscher, Peter M.;Knight, Julian C.;Psaty, Bruce M.;Ripatti, Samuli;Teumer, Alexander;Frayling, Timothy M.;Metspalu, Andres;van Meurs, Joyce B. J.;Franke, Lude
通讯作者：
Franke, Lude
影响因子：
29.4
作者：
Romanos, Jihane;Van Diemen, Cleo C.;Wijmenga, Cisca
通讯作者：
Wijmenga, Cisca
影响因子：
24.5
作者：
Nisticò, L;Fagnani, C;Stazi, MA
通讯作者：
Stazi, MA
影响因子：
64.8
作者：
通讯作者：
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影响因子：
30.8
作者：
通讯作者：
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