An epitope from Acanthamoeba castellanii that cross-react with proteolipid protein 139-151-reactive T cells induces autoimmune encephalomyelitis in SJL mice
An epitope from Acanthamoeba castellanii that cross-react with proteolipid protein 139-151-reactive T cells induces autoimmune encephalomyelitis in SJL mice
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DOI：
10.1016/j.jneuroim.2009.11.006
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发表时间：
2010-02-26
影响因子：
3.3
通讯作者：
Reddy, Jay
中科院分区：
文献类型：
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作者：
Massilamany, Chandirasegaran;Steffen, David;Reddy, Jay
我们在此报道，来自棘阿米巴castellanii （ACA）的表位（aa, 83-95）在SJL/J小鼠中诱导实验性自身免疫性脑脊髓炎（EAE）的临床症状，使人想起髓磷脂蛋白脂蛋白（PLP） 139-151通过IA(s)/四聚体诱导的疾病。我们证明ACA 83-95和PLP 139-151都能产生抗。特异性交叉反应CD4 T细胞和T细胞分泌相同的细胞因子模式，并以相似的70诱导EAE。这些结果可能为多发性硬化症和aca诱导的肉芽肿性脑炎的发病机制提供见解(C) 2009 Elsevier B V.版权所有
We report here that an epitope (aa, 83-95) derived from Acanthamoeba castellanii (ACA) induces clinical signs of experimental autoimmune encephalomyelitis (EAE) in SJL/J mice reminiscent of the disease Induced with myelin proteolipid protein (PLP) 139-151 By using IA(s)/tetramers. we demonstrate that both ACA 83-95 and PLP 139-151 generate anti.-en-specific cross-reactive CD4 T cells and the T cells secrete identical patterns of cytokines and induce EAE with a similar seventy. These results may provide insights into the pathogenesis of multiple sclerosis and ACA-induced granulomatous encephalitis (C) 2009 Elsevier B V. All rights reserved