Isolation of geodiastatins 1 and 2 from the marine sponge Geodia mesotriaena.
Isolation of geodiastatins 1 and 2 from the marine sponge Geodia mesotriaena.
复制标题
从海洋海绵 Geodia mesotriaena 中分离出 geodiastatins 1 和 2。
DOI：
10.1021/np50017a015
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发表时间：
1981
影响因子：
5.1
通讯作者：
Hasler,JA
中科院分区：
文献类型：
--
作者：
Pettit,GR;Rideout,JA;Hasler,JA
An aqueousextract of the Gulf of California Geodia mesotriaena von Lendenfeld (Porifera) has been found to contain two chromoprotein antineoplastic agents designated geodiastatins 1 and 2. The active brownish-black proteins from this siliceous sponge were found to contain major (> lr/) amounts of silicon and to inhibit growthof the murine P388 lymphocytic leukemia. A related protein (geodiatoxin 1) was found to be toxic at 0 mg/kg (LLLon, mouse).
