Effects of abstinence and family history for alcoholism on platelet adenylyl cyclase activity
Effects of abstinence and family history for alcoholism on platelet adenylyl cyclase activity
复制标题
DOI：
10.1111/j.1530-0277.1998.tb05903.x
复制
发表时间：
1998-12-01
期刊：
影响因子：
--
通讯作者：
Tabakoff, B
中科院分区：
文献类型：
--
作者：
Menninger, JA;Barón, AE;Tabakoff, B
在 32 名酒精依赖受试者和 27 名对照受试者中测量了血小板腺苷酸环化酶 (AC) 活性，这些受试者被归类为酗酒家族史阳性 (FHP) 或家族史阴性 (FHN)。在酒精组停止大量饮酒后不久进行访谈和血样采集，并在戒酒监测的第一周和第二周结束时重复采集血样。对照受试者接受了相同的访谈，并在访谈时提供了血样。当受试者未根据 FHP 或 FHN 状态进行隔离时，在研究开始时或戒酒 1 周或 2 周后，对照组和酗酒者之间的基础、氟化铯 (CsF) 或毛喉素刺激的平均 AC 活性没有统计学上的显着差异。另一方面，在酗酒的 2 周清醒过程中，FHP 酒精依赖受试者的 CsF 刺激的 AC 活性显着下降 (p = 0,03)，清醒 2 周后，FHP 酒精依赖受试者的平均 CsF 刺激的 AC 活性显着低于 FHN 对照组 (p = 0,04)，而 FHN 酒精依赖受试者的 CsF 刺激的 AC 活性与 FHN 对照组没有显着差异此时，当所有受试者被汇总并分类为 FHP 或 FHN 时，FHP 和 FHN 受试者组之间平均 CsF 刺激的 AC 活性存在显着差异（p = 0.02），遗传因素和禁欲似乎在确定酒精和非酒精受试者的低血小板 AC 活性方面发挥作用，特别是 CsF 刺激的血小板 AC 活性似乎可以作为遗传易患酒精中毒的特征标记，但近期男性酗酒酗酒是一个可以掩盖 FHP 和 FHN 受试者之间差异的因素。
Platelet adenylyl cyclase (AC) activity was measured in 32 alcohol-dependent subjects and 27 control subjects who were categorized as either family history-positive (FHP) or family history-negative (FHN) for alcoholism, The interview and blood sample collections were performed shortly after cessation of heavy drinking in the alcoholic group, and repeat blood samples were obtained at the end of the first and second weeks of monitored abstinence, Control subjects received the same interview and provided blood samples at the time of the interview. When subjects were not segregated for FHP or FHN status, there were no statistically significant differences in basal, cesium fluoride (CsF)-, or forskolin-stimulated mean AC activities between the controls and the alcoholics, at study entry or with 1 or 2 weeks of abstinence. On the other hand, over the 2-week course of sobriety from heavy drinking, the CsF-stimulated AC activity of FHP alcohol-dependent subjects decreased significantly (p = 0,03), FHP alcohol-dependent subjects after 2 weeks of sobriety had significantly lower mean CsF-stimulated AC activity than FHN controls (p = 0,04), whereas the FHN alcoholic subjects' CsF-stimulated AC activity did not differ significantly from FHN controls at this point in time, When all subjects were pooled and then categorized as either FHP or FHN, there was a significant difference in mean CsF-stimulated AC activity (p = 0.02) between the FHP and FHN subject groups, Genetic factors and abstinence appear to have roles in determining low platelet AC activity in alcoholic and nonalcoholic subjects, CsF-stimulated platelet AC activity, in particular, appears to act as a trait marker for a genetic vulnerability to developing alcoholism, but recent heavy drinking in male alcoholics is a factor that can mask differences between FHP and FHN subjects.