Neutralizing antibodies against human papillomavirus types 16, 18, 31, 52, and 58 in serum samples from women in Japan with low-grade cervical intraepithelial neoplasia
Neutralizing antibodies against human papillomavirus types 16, 18, 31, 52, and 58 in serum samples from women in Japan with low-grade cervical intraepithelial neoplasia
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DOI：
10.1128/cvi.00197-08
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发表时间：
2008-10-01
影响因子：
--
通讯作者：
Kanda, Tadahito
中科院分区：
文献类型：
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作者：
Ochi, Hiroyuki;Kondo, Kazunari;Kanda, Tadahito
我们有非常有限的信息，血清中和抗体的妇女自然感染的人乳头瘤病毒（HPV）的因果关系与宫颈癌。在这项研究中，从217名日本妇女的低度宫颈上皮内瘤样病变血清样本进行了检查，其对HPV 16，-18，-31，-52，和-58假病毒粒子的中和活性。84例患者（39%）、35例患者（16%）、17例患者（8%）和1例患者分别对其中一种、两种、三种和四种类型的中和抗体呈阳性。中和抗体的存在并不总是与血液采集时采集的宫颈拭子中HPV DNA的检测相关。发现大多数血清的中和滴度（范围在40和640之间）在24个月后收集的第二份血清中是保守的，与第二份宫颈拭子中HPV DNA的出现无关。这些数据强烈表明，HPV感染诱导低水平的抗HPV中和抗体，并维持很长一段时间。
We have very limited information on serum neutralizing antibody in women naturally infected with the human papillomaviruses (HPVs) that are causally associated with cervical cancer. In this study, serum samples collected from 217 Japanese women with low-grade cervical intraepithelial neoplasia were examined for their neutralizing activities against HPV16, -18, -31, -52, and -58 pseudovirions. Eighty-four patients (39%), 35 patients (16%), 17 patients (8%), and 1 patient were positive for neutralizing antibodies against one, two, three, and four of these types, respectively. Presence of neutralizing antibody did not always correlate with detection of HPV DNA in cervical swabs collected at the time of blood collection. The neutralizing titers of the majority of sera, ranging between 40 and 640, were found to be conserved in the second sera, collected 24 months later, independently of emergence of HPV DNA in the second cervical swabs. The data strongly suggest that HPV infection induces anti-HPV neutralizing antibody at low levels, which are maintained for a long period of time.