24-HOUR METABOLIC-RATE IN INSOMNIACS AND MATCHED NORMAL SLEEPERS
24-HOUR METABOLIC-RATE IN INSOMNIACS AND MATCHED NORMAL SLEEPERS
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DOI：
10.1093/sleep/18.7.581
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发表时间：
1995-09-01
期刊：
影响因子：
5.6
通讯作者：
ARAND, DL
中科院分区：
文献类型：
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作者：
BONNET, MH;ARAND, DL
在36小时的睡眠实验室住院期间，对10个客观定义的失眠症和年龄，性别和体重匹配的正常卧铺的组组进行了评估。失眠症被定义为夜间的唤醒时间增加，但同期第二阶段和眼睛运动快速运动。正如预期的那样，与正常人相比，整个评估期间，在整个评估期间情绪状况量表的混乱，张力和抑郁症以及活力下降。失眠症在短期记忆测试和桅杆上的记忆力也降低了。这些表现和情绪差异并不是嗜睡的次要，因为失眠症在整个评估期间也显着增加了多个睡眠潜伏期测试（MSLT）值。结合白天的一致情绪，性能和MSLT差异以及夜间的睡眠差异，整个白天和整个睡眠一夜都在夜间进行的全身VO2始终在失眠点的所有测量点上都持续提高。到正常人。即使在夜间包含唤醒时间的周期中的代谢值之后，代谢率的夜间数量仍然存在，或者从数据集中消除了唤醒。结论是，报告的慢性失眠的患者可能患有更普遍的高伴疾病（在此衡量的是，代谢率增加了24小时），这可能导致白天症状和夜间夜间睡眠不佳。未来的研究需要探索降低高音的24小时失眠治疗策略。
Groups of 10 objectively defined insomniacs and age-, sex- and weight-matched normal sleepers were evaluated on sleep, performance, mood, personality and metabolic measures over a 36-hour sleep laboratory stay. Insomniacs were defined to have increased wake time during the night but also had decreased stage 2 and rapid eye movement sleep. As expected insomniacs reported increased confusion, tension and depression and decreased vigor on the profile of mood states mood scale throughout the evaluation period as compared to the normals. Insomniacs also had decreased memory ability on the short-term memory test and the MAST. These performance and mood differences were not secondary to sleepiness because the insomniacs also had significantly increased multiple sleep latency test (MSLT) values throughout the evaluation period. In conjunction with the consistent mood, performance and MSLT differences during the day and the sleep differences at night, whole body VO2, measured at intervals across the day and throughout one night of sleep, was consistently elevated at all measurement points in the insomniacs as compared to the normals. The nocturnal increase in metabolic rate remained even after metabolic values from periods during the night containing wake time or arousals were eliminated from the data set. It was concluded that patients who report chronic insomnia may suffer from a more general disorder of hyperarousal (as measured here by a 24-hour increase in metabolic rate) that may be responsible for both the daytime symptoms and the nocturnal poor sleep. Future studies need to explore 24-hour insomnia treatment strategies that decrease hyperarousal.