The origin of vesico-ureteric reflux in male newborns: further evidence in favour of a transient fetal urethral obstruction.
The origin of vesico-ureteric reflux in male newborns: further evidence in favour of a transient fetal urethral obstruction.
复制标题
男性新生儿膀胱输尿管反流的起源：支持短暂性胎儿尿道梗阻的进一步证据。
DOI：
10.1046/j.1464-410x.1996.00106.x
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
C. Schulman
中科院分区：
文献类型：
--
作者：
E. Avni;C. Schulman
目标
提出进一步的论据，支持胎儿早期发育期间发生的短暂性尿道梗阻作为男婴膀胱输尿管反流（VUR）起源的解释。
患者和方法
回顾了 25 名 VUR 男婴的超声检查和排尿性膀胱尿道造影 (VCUG) 结果，主要研究 VCUG 上的膀胱和尿道异常以及超声检查上的膀胱壁厚度。
结果
15 名患者发现膀胱或尿道异常，其中 5 名患者出现孤立性后尿道扩张，4 名患者出现后尿道扩张伴膀胱异常，2 名患者出现尿道管状外观，4 名患者出现膀胱颈收缩过度并伴有憩室。膀胱壁厚度范围为 1 至 8 毫米（平均 3.7），其中 8 名患者的厚度超过 5 毫米。
结论
这一系列新生儿 VUR 患者中发现的膀胱和尿道异常可以用子宫内可能发生的短暂性膀胱出口梗阻来解释。这些发现支持这样的理论：大量男婴 VUR 病例是由短暂的胎儿尿道梗阻引起的。
OBJECTIVE
To present further arguments supporting a transient urethral obstruction occurring during early fetal development as an explanation of the origin of vesico-ureteric reflux (VUR) in baby boys.
PATIENTS AND METHODS
The findings of ultrasonography and voiding cysto-urethrography (VCUG) in 25 baby boys with VUR were reviewed, studying mainly bladder and urethral anomalies on VCUG and bladder-wall thickness on ultrasonography.
RESULTS
A bladder or urethral anomaly was found in 15 patients, comprising isolated posterior urethral dilatation in five, posterior urethral dilatation with a bladder anomaly in four, tubular appearance of the urethra in two and bladder neck hypercontractility with diverticulae in four. Bladder-wall thickness ranged from 1 to 8 mm (mean 3.7) and in eight patients, the thickness exceeded 5 mm.
CONCLUSION
The bladder and urethral anomalies found in this series of patients with neonatal VUR could be explained by a transient bladder outlet obstruction that possibly occurred in utero. These findings support the theory that a significant number of cases of VUR seen in baby boys result from a transient fetal urethral obstruction.