Human Ovarian Reserve from Conception to the Menopause
Human Ovarian Reserve from Conception to the Menopause
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DOI：
10.1371/journal.pone.0008772
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发表时间：
2010-01-27
期刊：
影响因子：
3.7
通讯作者：
Kelsey, Thomas W.
中科院分区：
文献类型：
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作者：
Wallace, W. Hamish B.;Kelsey, Thomas W.
人类卵巢含有固定数量的未生长卵泡（ngf），这些卵泡在出生前就已形成，随着年龄的增长而减少，在50-51岁时达到更年期。本研究的目的是模拟从受孕到更年期人类卵巢中与年龄相关的NGFs群体。数据来自8个独立的定量组织学研究（n = 325），其中计算了从受孕后7周到51岁（中位32岁）的已知年龄的NGF种群。对数据集进行20个峰函数模型的拟合，根据得到的r(2)相关系数对结果进行排序。最后选择了排名最高的模型。我们的模型将从受孕到更年期的对数调整后的NGF种群匹配到五参数非对称双高斯累积（ADC）曲线（r(2) = 0.81）。当年龄限制在25岁以下时，ADC曲线r(2) = 0.95。我们估计，95%的女性到30岁时，其出生前最大NGF群体中只有12%存在，到40岁时，仅剩下3%。此外，我们还发现，大多数女性在成熟阶段的NGF募集率从出生到大约14岁都在增加，然后在绝经期减少。据我们所知，这是卵巢储备从受孕到更年期的第一个模型。该模型使我们能够估计任何给定年龄的卵巢中存在的NGF数量，表明NGF群体中81%的差异仅归因于年龄，并首次表明，据我们所知，NGF的招募率从出生到14岁增加，然后随着年龄的增长而下降，直到更年期。对人类卵巢储备动态的进一步了解将为健康妇女和那些在促性腺毒性癌症治疗中幸存下来的妇女提供更科学的生育咨询依据。
The human ovary contains a fixed number of non-growing follicles (NGFs) established before birth that decline with increasing age culminating in the menopause at 50-51 years. The objective of this study is to model the age-related population of NGFs in the human ovary from conception to menopause. Data were taken from eight separate quantitative histological studies (n = 325) in which NGF populations at known ages from seven weeks post conception to 51 years ( median 32 years) were calculated. The data set was fitted to 20 peak function models, with the results ranked by obtained r(2) correlation coefficient. The highest ranked model was chosen. Our model matches the log-adjusted NGF population from conception to menopause to a five-parameter asymmetric double Gaussian cumulative (ADC) curve (r(2) = 0.81). When restricted to ages up to 25 years, the ADC curve has r(2) = 0.95. We estimate that for 95% of women by the age of 30 years only 12% of their maximum pre-birth NGF population is present and by the age of 40 years only 3% remains. Furthermore, we found that the rate of NGF recruitment towards maturation for most women increases from birth until approximately age 14 years then decreases towards the menopause. To our knowledge, this is the first model of ovarian reserve from conception to menopause. This model allows us to estimate the number of NGFs present in the ovary at any given age, suggests that 81% of the variance in NGF populations is due to age alone, and shows for the first time, to our knowledge, that the rate of NGF recruitment increases from birth to age 14 years then declines with age until menopause. An increased understanding of the dynamics of human ovarian reserve will provide a more scientific basis for fertility counselling for both healthy women and those who have survived gonadotoxic cancer treatments.