Sound frequency dependence of duration mismatch negativity recorded from awake rats
Sound frequency dependence of duration mismatch negativity recorded from awake rats
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DOI：
10.1002/npr2.12090
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发表时间：
2019-12-01
影响因子：
2.5
通讯作者：
Nawa, Hiroyuki
中科院分区：
文献类型：
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作者：
Inaba, Hiroyoshi;Namba, Hisaaki;Nawa, Hiroyuki
目的利用失配负波（MMN）来评价脑在声环境中检测偏差的功能。MMN对声音持续时间的偏离最近作为精神分裂症的生物标志物引起了人们的注意。包括大鼠在内的非人类动物也表现出MMN样电位。因此，在非人类动物中研究MMN有助于阐明MMN产生的神经机制。然而，临床前MMN研究的持续时间偏差的结果是相互矛盾的。本文研究了不同频率的声刺激对大鼠类MMN电位时程偏差的影响。方法在自由活动的大鼠初级听觉皮层上放置一个电极，以500 ms的刺激起始时间记录事件相关电位，采用由50 ms时程的标准音和150 ms时程的异常音组成的oddball范式。将声音频率设置为三个条件：3、12和50 kHz。结果仅在12 kHz纯音频率条件下观察到依赖于背景规则性短时刺激历史的MMN样电位。结论大鼠类MMN电位的时距偏离受oddball范式的音频影响，提示大鼠具有明显的声音时距识别能力。
Aims The brain function that detects deviations in the acoustic environment can be evaluated with mismatch negativity (MMN). MMN to sound duration deviance has recently drawn attention as a biomarker for schizophrenia. Nonhuman animals, including rats, also exhibit MMN-like potentials. Therefore, MMN research in nonhuman animals can help to clarify the neural mechanisms underlying MMN production. However, results from preclinical MMN studies on duration deviance have been conflicting. We investigated the effect of sound frequency on MMN-like potentials to duration deviance in rats. Methods Event-related potentials were recorded from an electrode placed on the primary auditory cortex of free-moving rats using an oddball paradigm consisting of 50-ms duration tones (standards) and 150-ms duration tones (deviants) at a 500-ms stimulus onset asynchrony. The sound frequency was set to three conditions: 3, 12, and 50 kHz. Results MMN-like potentials that depended on the short-term stimulus history of background regularity were only observed in the 12-kHz tone frequency condition. Conclusions MMN-like potentials to duration deviance are subject to tone frequency of the oddball paradigm in rats, suggesting that rats have distinct sound duration recognition ability.