Synthesis of an anti-methicillin-resistant Staphylococcus aureus (MRSA) carbapenem via stannatrane-mediated Stille coupling
Synthesis of an anti-methicillin-resistant Staphylococcus aureus (MRSA) carbapenem via stannatrane-mediated Stille coupling
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DOI：
10.1021/ol005641d
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发表时间：
2000-04-20
期刊：
影响因子：
5.2
通讯作者：
Reider, PJ
中科院分区：
文献类型：
--
作者：
Jensen, MS;Yang, CH;Reider, PJ
介绍了碳青霉烯1的短合成方法。关键步骤是三氟化烯醇与氨基取代sp(3)碳的交叉偶联。这种交叉偶联，允许在一步中引入完整的侧链，利用锡烷作为杂烷基转移试剂。
A short synthesis of carbapenem 1 is described. The key step involves the cross-coupling of an enol triflate with an amino-substituted sp(3) carbon. This cross-couping, which allows the introduction of the complete side chain in one step, utilizes a stannatrane as the heteroalkyl transfer reagent.