Early-onset Alzheimer's disease is associated with greater pathologic burden
Early-onset Alzheimer's disease is associated with greater pathologic burden
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DOI：
10.1177/0891988706297086
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发表时间：
2007-03-01
影响因子：
2.6
通讯作者：
Cummings, Jeffrey L.
中科院分区：
文献类型：
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作者：
Marshall, Gad A.;Fairbanks, Lynn A.;Cummings, Jeffrey L.
阿尔茨海默病(AD)通常有两种亚型：早发性和晚发性。以往的研究表明，早发性AD患者有更多的神经炎性斑块(NPs)和神经原纤维缠结(NFTs)。本研究对25例确诊为AD患者的8个脑区进行了NP和NFT计数。对早发组和晚发组的平均区域NP和NFT计数的方差进行重复测量分析。在早发组中观察到显著的受试者间效应，表明总体NP和NFT负担更大(NP：F=6.8，df=1，P=.015；NFT：F=7.5，df=1，P=.012)。这一分析支持这样的假设，即早发性AD比晚发性AD与更大的病理负担有关。这表明，晚发性AD患者的认知储备比早发性患者更少，需要更少的病理变化才能表现出认知恶化。
Two subtypes of Alzheimer's disease (AD) have been commonly identified: early- and late-onset forms. Previous studies suggest that early-onset AD patients have more neuritic plaques (NPs) and neurofibrillary tangles (NFTs). In the current study, NP and NFT counts were performed for 8 brain regions in 25 subjects with definite AD. A repeated-measures analysis of variance of mean regional NP and NFT counts for early- and late-onset groups was performed. A significant between-subject effect indicating greater overall NP and NFT burden in the early-onset group was observed (NP: F = 6.8, df = 1, P =.015; NFT: F = 7.5, df = 1, P =.012). This analysis supports the hypothesis that early-onset AD is associated with greater pathologic burden than late-onset AD. This suggests that late-onset AD patients have less cognitive reserve than early-onset patients and require fewer pathologic changes to exhibit cognitive deterioration.