CAMPYLOBACTER-RECTUS IN HUMAN PERIODONTITIS
CAMPYLOBACTER-RECTUS IN HUMAN PERIODONTITIS
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DOI：
10.1111/j.1399-302x.1993.tb00565.x
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发表时间：
1993-08-01
影响因子：
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通讯作者：
SLOTS, J
中科院分区：
文献类型：
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作者：
RAMS, TE;FEIK, D;SLOTS, J
研究了牙周炎病变中的直肠弯曲杆菌(原直肠弯曲杆菌)与年龄和性别分布、与疾病活动性牙周炎的关系、牙周清理术的反应和体外药敏情况。用纸尖收集直肠弯曲菌，在VMGA III中运输，将其接种于非选择性浓缩布鲁氏菌血琼脂和Hammond‘s选择性培养基上，两者均为厌氧培养。在1654例牙周炎患者中，80%的患者恢复了直肌。尽管生物体表现出相似的年龄和性别，但在培养阳性的成年人中，其比例恢复与年龄的增加呈负相关(r=0.999，P<；0.001)。在一项对93名接受维持治疗的成人牙周炎患者进行的24个月的纵向研究中，这种微生物与疾病活动性呈正相关(汇总优势比=2.95)。20例培养阳性的成人牙周炎患者接受局部牙周清创后，直肌的比例从8.2%下降到0.7%。该菌对盐酸四环素、甲硝唑、青霉素G和环丙沙星具有较高的体外敏感性。这些发现进一步描述了直弧菌在人类牙周炎中的流行病学和潜在的致病作用。
Campylobacter rectus (formerly Wolinella recta) in periodontitis lesions was studied relative to age and sex distribution, relationship to disease-active periodontitis, response to periodontal debridement and in vitro antimicrobial susceptibility. Subgingival C. rectus was collected with paper points, transported in VMGA III and plated onto nonselective enriched brucella blood agar and Hammond's selective medium for C. rectus, both incubated anaerobically. C. rectus was recovered from 80% of 1654 periodontitis patients. Although the organism showed similar age and sex occurrence, its proportional recovery in culture-positive adults was inversely related to increasing age (r = 0.999, P < 0.001). The organism was positively associated (summary odds ratio = 2.95) with disease activity in a 24-month longitudinal study of 93 adult periodontitis patients on maintenance therapy. C. rectus decreased from 8.2% to 0.7% following local periodontal debridement of 20 culture-positive adult periodontitis patients. The organism exhibited high in vitro susceptibility to therapeutic levels of tetracycline hydrochloride, metronidazole, penicillin G and ciprofloxacin. These findings further delineate the epidemiology and potential pathogenic role of C. rectus in human periodontitis.