Wheel running predicts resilience to tumors in old mice.
Wheel running predicts resilience to tumors in old mice.
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轮子运转预测老年小鼠对肿瘤的恢复能力。
DOI：
10.1080/20010001.2019.1676104
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Goh,Jorming
中科院分区：
文献类型：
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作者：
Zhu,Lida;Wang,Juan;Pettan-Brewer,Christina;Ladiges,Warren;Goh,Jorming
由于缺乏确定年龄相关慢性病风险的预测性措施，老龄化干预研究受到阻碍。在这方面，对身体复原力的评估可能是有益的，特别是对癌症等与年龄有关的疾病。自愿车轮跑步是一种压力较小的体力活动，在小鼠身上很容易量化，但尚未被研究为随着年龄的增长而抵抗肿瘤侵袭性的预测因素。4、12、20和28个月龄的雄性C57BL/6小鼠被允许接触倾斜的笼内跑轮3天。三个月后，小鼠皮下注射B16黑色素瘤细胞，并跟踪观察两周后收获。在4个月龄组中，跑步距离与肿瘤负荷之间没有相关性。12个月龄组有下降趋势，20、28个月龄组跑步距离与肿瘤负荷呈负相关(P<；P<0.05)。20个月龄组中跑距离较长的小鼠与跑较短距离的同龄组小鼠相比，肿瘤侵袭性评分较低。总而言之，短期运动能力可能是小鼠对癌症以及其他年龄相关疾病的抵抗力的标志。
Aging intervention studies are hampered by the lack of predictive measures for determination of individuals at risk of age-associated chronic disease. Assessment of physical resilience could be informative in this regard, especially for age-related diseases such as cancer. Voluntary wheel running is a mildly stressful physical activity that is easily quantifiable in the mouse but has not been studied as a predictor of resistance to tumor invasiveness with increasing age. Male C57BL/6 mice in cohorts of 4, 12, 20, and 28 months of age were allowed access to a slanted in-cage running wheel for 3 days. Three months later, mice were injected subcutaneously with B16 melanoma tumor cells and followed for two weeks before harvesting. No relation was observed between running distance and tumor burden in the 4-month age group. The 12-month age group showed a trend, and the 20- and 28-month age groups showed a negative correlation (P< 0.05) between running distance and tumor burden. Mice in the 20-month age group that ran longer distances had lower tumor invasive scores compared to mice in the same age group that ran shorter distances. In conclusion, short term exercise capability could be a marker for resilience to cancer, and possibly other age-related disease conditions, in mice.