Vegetables, fruit, and colon cancer in the Iowa Women's Health Study.
Vegetables, fruit, and colon cancer in the Iowa Women's Health Study.
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爱荷华州妇女健康研究中的蔬菜、水果和结肠癌。
DOI：
10.1093/oxfordjournals.aje.a116921
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发表时间：
1994
影响因子：
5
通讯作者：
Potter,JD
中科院分区：
文献类型：
--
作者：
Steinmetz,KA;Kushi,LH;Bostick,RM;Folsom,AR;Potter,JD
以前的流行病学研究表明，蔬菜和水果的摄入量与结肠癌风险之间存在负相关；这些研究中很少有前瞻性的或专注于女性的。这份报告描述了一项前瞻性队列研究的结果，研究对象是年龄在55-69岁的41,837名女性，她们在1986年完成了一份包含127项食物频率的问卷，并通过爱荷华州健康登记处对癌症发病率进行了为期5年的监测。在应用特定的排除标准后，212例结肠癌病例和167,447人年可用于分析。15组蔬菜和水果的摄入量和膳食纤维是主要感兴趣的因素。大蒜摄入量与风险呈负相关，最高摄入量与最低摄入量经年龄和能量调整后的相对危险度为0.68(95%可信区间0.46-1.02)。所有蔬菜和膳食纤维的摄入量也观察到了负相关，年龄和能量调整后的最高和最低摄入量四分位数的相对风险分别为0.73(95%可信区间0.47-1.13)和0.80(95%可信区间0.49-1.31)。其他蔬菜和水果组的关联性不那么明显.美国流行病学杂志1994；139：1-15.
Previous epidemiologic studies have shown an inverse association between vegetable and fruit consumption and colon cancer risk; few of these studies have been prospective or have focused on women. This report describes results from a prospective cohort study of 41,837 women aged 55–69 years who completed a 127-item food frequency questionnaire in 1986 and were monitored for cancer incidence for 5 years via the State Health Registry of Iowa. After specific exclusion criteria were applied, 212 colon cancer cases and 167,447 person-years were available for analysis. Intakes of 15 vegetable and fruit groups and dietary fiber were the major factors of interest. Consumption of garlic was Inversely associated with risk, with an age- and energy-adjusted relative risk of 0.68 (95% confidence interval (CI) 0.46–1.02) for the uppermost versus the lowermost consumption levels. Inverse associations were also observed for intakes of all vegetables and dietary fiber, age- and energy-adjusted relative risks for the uppermost versus the lowermost intake quartiles were 0.73(95% CI 0.47–1.13) and 0.80(95% CI 0.49–1.31), respectively. Associations for the other vegetable and fruit groups were less remarkable.Am J Epidemiol1994;139:1–15.