Limbal Stem Cell Transplantation for Gelatinous Drop-like Corneal Dystrophy
Limbal Stem Cell Transplantation for Gelatinous Drop-like Corneal Dystrophy
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角膜缘干细胞移植治疗凝胶状水滴样角膜营养不良
DOI：
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发表时间：
2013
影响因子：
2
通讯作者：
M. Nowroozzadeh
中科院分区：
文献类型：
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作者：
H. Movahedan;Hamid Reza Anvari;M. Nowroozzadeh
目的报道同种异体角膜缘干细胞移植治疗复发性凝胶状滴状角膜营养不良（GDLD）的疗效。方法对3例复发性GDLD患者的4只眼行同种异体角膜缘干细胞移植术。两眼同时行穿透性角膜移植术，另两眼同时行浅层角膜切除术。主要观察指标为最佳眼镜矫正视力、眼压和角膜透明度。结果患者年龄28 ~ 63岁。术后平均随访时间为23±10（中位数，22;范围，12-36）个月。平均视力从术前的2.70±0.61 logMAR改善至最终术后访视时的1.05±0.06 logMAR（P=0.066）。基线时所有眼睛的眼压均正常，并且在所有术后访视时均保持在正常范围内。随访期间，所有角膜均保持光滑透明，无排斥反应或复发。所有患者在最终随访前均保持动态视力。结论角膜缘干细胞移植是治疗GDLD的有效方法。
Purpose To report the outcomes of allograft limbal stem cell transplantation for recurrent gelatinous drop-like corneal dystrophy (GDLD). Methods In this non-comparative interventional case series, 4 eyes of 3 consecutive patients with recurrent GDLD underwent allograft limbal stem cell transplantation. Two eyes underwent concomitant penetrating keratoplasty while the other two underwent simultaneous superficial keratectomy. Main outcome measures were best spectacle corrected visual acuity, intraocular pressure and corneal clarity. Results Patient age ranged from 28 to 63 years. Mean follow-up after surgery was 23±10 (median, 22; range, 12-36) months. Mean visual acuity improved from 2.70±0.61 logMAR preoperatively to 1.05±0.06 logMAR at final postoperative visit (P=0.066). Intraocular pressure was normal in all eyes at baseline and remained within normal limits at all postoperative visits. All corneas remained smooth and clear during the follow-up period with no episode of rejection or recurrence. All patients maintained ambulatory vision until final follow-up. Conclusion The present study provides further evidence that limbal stem cell transplantation may be an effective therapeutic alternative in patients with GDLD.
家族性上皮下角膜淀粉样变性（凝胶状水滴样角膜营养不良）：排除与乳铁蛋白基因的连锁。
DOI：
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发表时间：
1998
期刊：
Molecular vision [electronic resource].
影响因子：
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作者：
Klintworth,GK;Sommer,JR;Obrian,G;Han,L;Ahmed,MN;Qumsiyeh,MB;Lin,PY;Basti,S;Reddy,MK;Kanai,A;Hotta,Y;Sugar,J;Kumaramanickavel,G;Munier,F;Schorderet,DF;ElMatri,L;Iwata,F;Kaiser-Kupfer,M;Nagata,M;Nakayasu,K;Hej
通讯作者：
Hej
用于眼表重建的角膜缘移植——综述。
DOI：
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发表时间：
1991
期刊：
Fortschritte der Ophthalmologie : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
影响因子：
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作者：
Tseng,SC;Tsai,RJ
通讯作者：
Tsai,RJ