Cancer and the FRA3B/FHIT fragile locus: it's a HIT.
Cancer and the FRA3B/FHIT fragile locus: it's a HIT.
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癌症和fra3b/fhit脆弱的基因座：这很受欢迎。
DOI：
10.1038/sj.bjc.6600937
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发表时间：
2003-05-19
影响因子：
8.8
通讯作者：
Croce, C M
中科院分区：
文献类型：
--
作者：
Huebner, K;Croce, C M
FHIT基因包含人类最活跃的常见染色体脆性区域FRA3B，于1996年被发现，并被认为是一种重要的人类癌症的肿瘤抑制基因。七年后，经过350多份报告，关于它的肿瘤抑制作用的早期问题得到了解答。最近关于FHIT丢失在人类主要类型癌症中的作用的研究报告与高增殖和低凋亡指数、结节阳性、错配修复蛋白丢失、进展的可能性和生存减少有关。
The FHIT gene encompassing the most active common human chromosomal fragile region, FRA3B, was discovered in 1996 and proposed as a tumour suppressor gene for important human cancers. Seven years and more than 350 reports later, early questions concerning its tumour suppressor role have been answered. Recent studies on the role of Fhit loss in major types of human cancers report association with high proliferative and low apoptotic indices, node positivity, loss of mismatch repair protein, likelihood of progression and reduced survival.