The risk of a contralateral breast cancer among women diagnosed with ductal and lobular breast carcinoma in situ: data from the Connecticut Tumor Registry
The risk of a contralateral breast cancer among women diagnosed with ductal and lobular breast carcinoma in situ: data from the Connecticut Tumor Registry
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DOI：
10.1016/s0960-9776(03)00152-8
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发表时间：
2003-12-01
期刊：
影响因子：
3.9
通讯作者：
Holford, T
中科院分区：
文献类型：
--
作者：
Claus, EB;Stowe, M;Holford, T
背景：被诊断为原位乳腺癌的女性患对侧乳腺癌的风险增加。这种风险的大小以及这种风险与年龄、诊断时间、组织学亚型和首次乳腺癌治疗之间的关系仍在继续确定。方法：在1975年1月1日至1998年3月14日期间，使用Kaplan-Meier估计方法对4198名确诊为原位乳腺癌并向康涅狄格州肿瘤登记处（CTR）报告的女性进行对侧乳腺癌发病风险的检测。采用Cox比例风险模型评估手术治疗效果。放射治疗，诊断时的年龄，种族，组织学，婚姻状况，乳房内的解剖位置，以及诊断后的时间对这种风险的影响。结果：在最初诊断为导管性原位乳腺癌（DCIS）的女性中，被诊断为对侧乳腺癌的累积5年和10年概率分别为4.3%（95%可信区间，3.6-5.0%）和6.8%（95%可信区间，5.5-8.2%）。这些风险是没有乳腺癌病史的女性的3.35倍，但与被诊断为乳腺非转移性浸润性导管癌的女性相似。最初诊断为小叶乳腺原位癌（LCIS）的女性被诊断为对侧乳腺癌的累积5年和10年概率分别为11.9%（95%可信区间，9.5-14.3%）和13.9%（95%可信区间，11.0-16.8%）。结论：被诊断为LCIS的女性在首次乳房原发后的前六个月内被诊断为对侧乳腺癌的可能性是DCIS女性的2.6倍（95%可信区间，2.0-3.4%）。发生对侧乳腺癌超过6个月的风险与手术或放疗、诊断后的时间、诊断时的年龄、组织学、种族、婚姻状况或乳房内癌症的解剖位置无关。(C) 2003, Elsevier Ltd.出版
Background: Women diagnosed with breast carcinoma in situ are at increased risk for developing a contralateral breast cancer. The magnitude of this risk and the relationship between this risk and age, time since diagnosis, histologic subtype, and treatment for the first breast cancer is continuing to be defined.Methods: The risk of developing a contralateral breast cancer is examined among 4198 women diagnosed with breast carcinoma in situ and reported to the Connecticut Tumor Registry (CTR) between January 1, 1975 and March 14, 1998 using Kaplan-Meier estimation. A Cox proportional hazards model is used to assess the effect of surgical treatment. radiation therapy, age at diagnosis, race, histology, marital status, anatomic location within the breast, and time since diagnosis upon this risk.Results: The cumulative 5- and 10-year probabilities of being diagnosed with a contralateral breast cancer among women initially diagnosed with a ductal breast carcinoma in situ (DCIS) were 4.3% (95% confidence interval, 3.6-5.0%) and 6.8% (95% confidence interval, 5.5-8.2%), respectively. These risks are 3.35 times greater than those for women without a history of breast cancer but are similar to those for women diagnosed with non-metastatic invasive ductal carcinomas of the breast. The cumulative 5- and 10-year probabilities of being diagnosed with a contralateral breast cancer among women initially diagnosed with a lobular breast carcinoma in situ (LCIS) were 11.9% (95% confidence interval, 9.5-14.3%) and 13.9% (95% confidence interval, 11.0-16.8%), respectively.Conclusions: Women diagnosed with LCIS were 2.6 (95% confidence interval, 2.0-3.4%) times more likely than women with DCIS to be diagnosed with a contralateral breast cancer within the first six months of the first breast primary. The risk of developing a contralateral breast cancer more than 6 months after the initial breast cancer was independent of surgical or radiation therapy, time since diagnosis, age at diagnosis, histology, race, marital status, or anatomic location of the cancer within the breast. (C) 2003 Published by Elsevier Ltd.