Effects of 5-HT1A and 5-HT2A receptor stimulation on temporal differentiation performance in the fixed-interval peak procedure
Effects of 5-HT1A and 5-HT2A receptor stimulation on temporal differentiation performance in the fixed-interval peak procedure
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DOI：
10.1016/j.beproc.2005.06.007
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发表时间：
2006-02-28
影响因子：
1.3
通讯作者：
Szabadi, E
中科院分区：
文献类型：
--
作者：
Asgari, K;Body, S;Szabadi, E
我们检测了5-HT受体激动剂8-羟基-2-羟色胺（8-hydroxy-2-hydroxy-2-hydroxy-2-hydroxy）（二正丙氨基）四氢萘（8-OH-DPAT）和5-HT 2A/2C受体激动剂2，5-二甲氧基-4-碘苯丙胺（DOI）对固定间隔峰程序性能的影响，以及这些作用对5-HT 1A和5-HT 2A受体拮抗剂的敏感性（N-[2-（4-[2-甲氧基苯基]-1-哌嗪基]乙基]-N-2-吡啶基环己烷甲酰胺[WAY 100635]和酮色林）。训练大鼠在50分钟的时间段内按下杠杆进行食物强化，该时间段由32次试验组成，其中杠杆连续可用，间隔10秒的试验间隔。在16项试验中，自试验开始后30 s（固定间隔30 s），在第一次反应后进行强化。在16个随机插入（峰值/探针）试验中，省略了加固，杠杆在操作室中保持120 s。将探索试验中的缓解率与试验开始后的时间作图。达到峰值反应率的时间（t（峰值））和韦伯分数来自拟合每只大鼠数据的改良高斯曲线。8-OH-DPAT（0.05 mg kg（-1））降低t（峰值）并增加Weber分数; WAY-100635（0.1 mg kg（-1））可拮抗对t（峰值）的影响。DOI（0.25 mg kg（-1））也降低t（峰值）并增加Weber分数;酮色林（2 mg kg（-1））可拮抗t（峰值）的降低。5-HT 1A和5-HT 2A受体的刺激以定性相似的方式改变时间分化。(c)2005 Elsevier B. V.保留所有权利。
We examined the effects of the 5-HT, receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and 5-HT2A/2C receptor agonist 2,5-dimethoxy-4-iodoamphetamine (DOI) on performance on the fixed-interval peak procedure, and the sensitivity of these effects to 5-HT1A and 5-HT2A receptor antagonists (N-[2-(4-[2-methoxyphenyl]-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide [WAY 100635] and ketanserin). Rats were trained to press a lever for food reinforcement in 50 min sessions consisting of 32 trials in which the lever was continuously available, separated by 10 s inter-trial intervals. In 16 trials, reinforcement was delivered following the first response after 30 s had elapsed since trial onset (fixed-interval 30 s). In 16 randomly interposed (peak/probe) trials, reinforcement was omitted, and the lever remained in the operant chamber for 120 s. Response rate in probe trials was plotted against time from trial onset. Time to peak response rate (t(peak)) and the Weber fraction were derived from modified Gaussian curves fitted to each rat's data. 8-OH-DPAT (0.05 mg kg(-1)) reduced t(peak) and increased the Weber fraction; the effect on t(peak) was antagonized by WAY-100635 (0.1 mg kg(-1)). DOI (0.25 mg kg(-1)) also reduced t(peak) and increased the Weber fraction; the reduction of t(peak) was antagonized by ketanserin (2 mg kg(-1)). Stimulation of 5-HT1A and 5-HT2A receptors alters temporal differentiation in qualitatively similar ways. (c) 2005 Elsevier B.V. All rights reserved.