PERCUTANEOUS PENETRATION AND DISPOSITION OF TRICLOCARBAN IN MAN - BODY SHOWERING
PERCUTANEOUS PENETRATION AND DISPOSITION OF TRICLOCARBAN IN MAN - BODY SHOWERING
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DOI：
10.1080/00039896.1975.10666624
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发表时间：
1975-01-01
期刊：
影响因子：
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通讯作者：
MAIBACH, HI
中科院分区：
文献类型：
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作者：
SCHARPF, LG;HILL, ID;MAIBACH, HI
在人体淋浴后测定了14 C-3- 4，4 '-三氯碳酰苯胺（triclocarban，TCC）的经皮渗透和代谢处置。在进行淋浴研究前，给受试者单次静脉注射微量的14 C-三氯碳酰苯胺，以测定化合物的药理处置。静脉注射14 C-三氯卡班丙二醇溶液后，放射性迅速从血液中清除，血液清除半衰期为8.6小时。约54%的剂量经粪便排泄，21%的剂量经尿液排泄，尿液消除半衰期为10小时。受试者进行一次淋浴，使用约7克含2%14C-三氯卡班（以肥皂为基础）的肥皂全身起泡。采用特殊的采血和尿/粪便采集技术，以最大限度地减少有害的14 C-三氯卡班对样本的污染。6天后在粪便中回收了约0.23%的放射性剂量，2天后在尿液中回收了约0.16%的剂量。在所有采样时间，血液放射性水平均低于该方法的检测限（10 ppm）。
The percutaneous penetration and metabolic disposition of14C-3-4,4’-trichlorocarbanilide (triclocarban, TCC) after body showering has been determined in man.Single intravenous doses of trace amounts of14C-triclocarban were given to subjects to determine the pharmacologic disposition of the compound before conducting the shower study. Radioactivity was rapidly cleared from blood after intravenous administrations of14C-triclocarban in propylene glycol with a blood clearance half-life of 8.6 hours. About 54% of the dose was excreted in the feces and 21% of the dose in the urine with a urinary elimination half-life of ten hours. No radioactivity was detected in the saliva.Subjects took a single shower employing a whole body lather with approximately 7 gm of soap containing 2%14C-triclocarban on a soap basis. Special blood withdrawal and urinary/fecal collection techniques were utilized that minimized contamination of samples by extraneous14C-triclocarban. About 0.23% of the applied radioactive dose was recovered in the feces after six days and 0.16% of the dose in the urine after two days. At all sampling times blood levels of radioactivity were below the detection limit of the method (10 part per billion).