Effect of combined treatment with sub-Tenon injection of triamcinolone acetonide and photodynamic therapy in Japanese patients with age-related macular degeneration
Effect of combined treatment with sub-Tenon injection of triamcinolone acetonide and photodynamic therapy in Japanese patients with age-related macular degeneration
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DOI：
10.1007/s10384-009-0703-6
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发表时间：
2009-09-01
影响因子：
2.4
通讯作者：
Yamashita, Hidetoshi
中科院分区：
文献类型：
--
作者：
Saito, Koko;Yamamoto, Teiko;Yamashita, Hidetoshi
为评价曲安奈德(STTA)单次Tenon下注射联合光动力疗法(PDT)治疗日本老年性黄斑变性(AMD)的疗效，对111例(111只眼)AMD患者的临床资料进行回顾性分析。45只眼接受STTA联合PDT治疗，66只眼单独接受PDT治疗。通过Kaplan-Meier生存分析评估视力丧失时间，定义为最小分辨率(LogMAR)单位改变0.3或更多的对数，以及重新治疗的时间。COX回归模型被用来估计这些终点的风险比，以研究临床风险特征。接受STTA和PDT联合治疗的患者再治疗的风险显著低于单纯接受PDT的患者(风险比，0.59；95%可信区间，0.36-0.99)。这种有益的关联只在没有息肉状脉络膜血管病变(PCV)的患者中发现。然而，与单用PDT相比，STTA和PDT联合治疗在减少视力损失方面并无益处，而在减少日本患者AMD的再治疗方面，STTA和PDT联合治疗具有有益效果。那些有PCV损害的人没有从这种额外的治疗中受益。
To evaluate the benefit of the combination of a single sub-Tenon injection of triamcinolone acetonide (STTA) with photodynamic therapy (PDT) for the treatment of age-related macular degeneration (AMD) in Japanese patients.The medical records of 111 eyes of 111 patients were reviewed retrospectively. Forty-five eyes underwent combined treatment with STTA and PDT, and 66 eyes underwent PDT alone. Time to vision loss, defined as a change of 0.3 or more logarithm of minimum angle of resolution (logMAR) units, and time to retreatment were evaluated using the Kaplan-Meier survival analyses. Cox regression models were used to estimate the hazard ratios for those end points to investigate clinical risk characteristics.Patients who underwent combined STTA with PDT had a significantly lower risk of retreatment than did those who underwent PDT alone (hazard ratio, 0.59; 95% confidence interval, 0.36-0.99). This beneficial association was found only in patients without polypoidal choroidal vasculopathy (PCV) lesions. However, combined treatment with STTA and PDT had no beneficial effect in reducing visual loss when compared with treatment with PDT alone.Combined treatment with STTA and PDT had a beneficial effect in reducing retreatment of AMD in Japanese patients. Those who had PCV lesions did not benefit from this additional treatment.