Nanopore/electrode structures for single-molecule biosensing
Nanopore/electrode structures for single-molecule biosensing
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DOI：
10.1016/j.electacta.2010.03.051
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发表时间：
2010-11-30
影响因子：
6.6
通讯作者：
Albrecht, Tim
中科院分区：
文献类型：
--
作者：
Ayub, Mariam;Ivanov, Aleksandar;Albrecht, Tim
生物和固态纳米孔作为超快DNA片段大小和测序设备最近引起了人们的极大兴趣，它们的潜力远远超出了DNA测序，特别是纳米孔提供了生理相关浓度下的单分子（生物）传感的视角，这是研究蛋白质/蛋白质或蛋白质/DNA相互作用的关键。将电极结构集成到固态纳米孔设备中还可以控制和快速切换孔我们介绍了该领域的一些最新工作，即用于单（生物）分子传感的纳米孔/电极结构的制造和表征。具体来说，我们介绍了一种基于离子电流反馈（ICF）控制的电沉积技术来制造直径小于20纳米的超小金属纳米孔的新技术。它提供了对孔电导的精确控制扩展到各种不同的金属(C) 2010爱思唯尔有限公司版权所有
Biological and solid-state nanopores have recently attracted much interest as ultrafast DNA fragment sizing and sequencing devices Their potential however goes far beyond DNA sequencing In particular nanopores offer perspectives of single-molecule (bio)sensing at physiologically relevant concentrations which is key for studying protein/protein or protein/DNA interactions Integration of electrode structures into solid-state nanopore devices moreover enables control and fast switching of the pore properties e g for active control of biopolymer transport through the nanopore We present some of recent work in this area namely the fabrication and characterization of nanopore/electrode architectures for single-(bio)molecule sensing Specifically we introduce a new technique to fabricate ultra-small metal nanopores with diameters smaller than 20 nm based on ion current feedback (ICF) controlled electrodeposition It offers precise control of the pore conductance is easily multiplexed and can be extended to a wide range of different metals (C) 2010 Elsevier Ltd All rights reserved