Characterization of coronary atherosclerotic plaque using multicontrast MRI acquired under simulated in vivo conditions.
Characterization of coronary atherosclerotic plaque using multicontrast MRI acquired under simulated in vivo conditions.
复制标题
使用在模拟体内条件下获得的多重对比 MRI 表征冠状动脉粥样硬化斑块。
DOI：
10.1002/jmri.20687
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Oshinski,JohnN
中科院分区：
文献类型：
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作者：
Sun,Binjian;Giddens,DonP;LongJr,Robert;Taylor,WRobert;Weiss,Diana;Joseph,Giji;Vega,David;Oshinski,JohnN
1)模拟活体条件下新鲜切除的冠状动脉和2)保存的冠状动脉。材料与方法对13条新鲜切除的人冠状动脉分别进行T1加权(T1W)、T2加权(T2W)、质子密度加权(PDW)和扩散加权(DW)磁共振成像。血管在与MR兼容的组织培养室中使用4.7特斯拉小口径磁共振扫描仪进行成像。然后，8条血管被保存在缓冲的福尔马林中，并按照相同的成像方案重新扫描。应用三维空间惩罚模糊C均值(3D-SPFCM)技术对不同斑块成分进行分类。结果对于大多数斑块成分，新鲜扫描和保存扫描的斑块表征结果无显著差异，与组织学参考标准的斑块特征也无显著差异。在血栓的情况下，新的和保存的图像之间的明显信号变化被识别。总体而言，保存条件下的MR扫描提供的信噪比(SNR)比新鲜阶段高1.8%~17.5%。结论冠状动脉保存不会改变斑块组织在多层增强MRI上的对比度，也不会显著改变斑块成分特征的结果。J·马根。雷森。想象2006年。©2006 Wiley-Liss，Inc.
PurposeTo compare coronary atherosclerotic plaque characterization using multicontrast MRI on: 1) freshly excised vessels under simulated in vivo conditions, and 2) preserved vessels.Materials and MethodsT1‐weighted (T1W), T2‐weighted (T2W), proton density‐weighted (PDW), and diffusion‐weighted (DW) MR images were acquired on 13 freshly excised human coronary arteries from explanted hearts. Vessels were imaged in an MR‐compatible tissue culture chamber using a 4.7 Tesla small‐bore MR scanner. Eight vessels were then preserved in buffered formalin and rescanned following the same imaging protocol. A three‐dimensional spatially penalized fuzzy C‐means (3D‐SPFCM) technique was applied to classify different plaque constituents. The classification results from vessels under “fresh” and “preserved” conditions were compared with corresponding histological sections.ResultsFor most plaque constituents, the plaque characterization results show no significant difference between fresh and preserved scans, and little difference between scans and the histological reference standard. In the case of thrombus, apparent signal changes between fresh and preserved images were identified. Overall, MR scans conducted under preserved conditions provided a 1.8% to 17.5% greater signal‐to‐noise ratio (SNR) than those conducted in the fresh stage.ConclusionPreservation of coronary vessels did not alter the contrast between plaque tissues on multicontrast MRI, and did not significantly change the results of plaque constituent characterization. J. Magn. Reson. Imaging 2006. © 2006 Wiley‐Liss, Inc.