The exon 4 variations of Tim-1 gene are associated with rheumatoid arthritis in a Korean population
The exon 4 variations of Tim-1 gene are associated with rheumatoid arthritis in a Korean population
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DOI：
10.1016/j.bbrc.2004.01.154
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发表时间：
2004-03-19
影响因子：
3.1
通讯作者：
Chung, HT
中科院分区：
文献类型：
--
作者：
Chae, SC;Song, JH;Chung, HT
T细胞免疫球蛋白结构域和粘蛋白结构域（TIM）蛋白家族被鉴定为在T细胞上表达。TIM-1是Tim家族的成员之一，被认为是与Th 2偏向的免疫应答的发展相关的膜蛋白，并且选择性地在Th 2细胞上表达。在本研究中，我们分析了类风湿关节炎（RA）患者和对照组之间的基因型和等位基因频率的关联使用大样本量的Tim-1基因5383_5397del和5509_5511delCAA变异。我们进一步研究了这些变化与RA患者C反应蛋白（CRP）和类风湿因子（RF）水平之间的关系。虽然这些因素与RA患者外显子4变异无关，但RA患者5383_5397del变异位点（P = 0.015和0.014）和5509_5511delCAA变异位点（P = 0.0002和0.0001）的基因型和等位基因频率与非RA对照组相比差异有统计学意义。提示Tim-1基因第4外显子的变异可能与RA的易感性有关。(C)2004年爱思唯尔公司All rights reserved.
The family of T-cell immunoglobulin domain and mucin domain (TIM) proteins is identified to be expressed on T cells. A member of Tim family, TIM-1, is considered as a membrane protein that is associated with the development of Th2 biased immune responses and selectively expressed on Th2 cells. In the present study, we analyzed the association of genotype and allele frequencies between rheumatoid arthritis (RA) patients and the controls without RA using large samples size at 5383_5397del and 5509_5511delCAA variations of Tim-1 gene. We further investigated the relationships among these variations to C-reactive protein (CRP) and rheumatoid factor (RF) levels in RA patients. Although these factors were not associated with exon 4 variations in RA patients, the genotype and allele frequencies of 5383_5397del variation site (P = 0.015 and 0.014, respectively) as well as 5509_5511delCAA variation site (P = 0.0002 and 0.0001, respectively) in RA patients were significantly different from those in the non-RA controls. Our results strongly suggest that the variations of Tim-1 exon 4 might be associated with the susceptibility to RA. (C) 2004 Elsevier Inc. All rights reserved.