Development of human protein reference database as an initial platform for approaching systems biology in humans
Development of human protein reference database as an initial platform for approaching systems biology in humans
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DOI：
10.1101/gr.1680803
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发表时间：
2003-10-01
期刊：
影响因子：
7
通讯作者：
Pandey, A
中科院分区：
文献类型：
--
作者：
Peri, S;Navarro, JD;Pandey, A
人类蛋白质参考数据库（HPRD）是一个对象数据库，它集成了大量与人类蛋白质在健康和疾病中的功能相关的信息。从非冗余的2750种人类蛋白质的文献中提取有关数千种蛋白质相互作用、翻译后修饰、酶/底物关系、疾病关联、组织表达和亚细胞定位的数据。几乎所有的信息都是由生物学家手动获取的，他们在注释过程中阅读和解释了bbb30万篇发表的文章。这个数据库有一个直观的查询界面，可以方便地访问蛋白质的所有特征，它是使用开源技术构建的，将在http://www.hprd.org上免费提供给学术界。这个统一的生物信息学平台将有助于编目和挖掘大量的蛋白质组相互作用和改变，这些将在后基因组时代被发现。
Human Protein Reference Database (HPRD) is an object database that integrates a wealth of information relevant to the function of human proteins in health and disease. Data pertaining to thousands of protein-protein interactions, posttranslational modifications, enzyme/substrate relationships, disease associations, tissue expression, and subcellular localization were extracted from the literature for a nonredundant set of 2750 human proteins. Almost all the information was obtained manually by biologists who read and interpreted >300,000 published articles during the annotation process. This database, which has an intuitive query interface allowing easy access to all the features of proteins, was built by using open source technologies and will be freely available at http://www.hprd.org to the academic community. This unified bioinformatics platform will be useful in cataloging and mining the large number of proteomic interactions and alterations that will be discovered in the postgenomic era.