Plasma neuropeptide-Y concentrations in humans exposed to military survival training
Plasma neuropeptide-Y concentrations in humans exposed to military survival training
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DOI：
10.1016/s0006-3223(99)00239-5
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发表时间：
2000-05-15
影响因子：
10.6
通讯作者：
Charney, DS
中科院分区：
文献类型：
--
作者：
Morgan, CA;Wang, S;Charney, DS
背景资料：神经肽Y（NPY）存在于大脑的广泛神经元系统中，并且以高浓度存在于杏仁核的细胞体和终末中。临床前研究表明，将NPY注射到杏仁核的中央核中起到中枢抗焦虑剂和缓冲剂的作用，以对抗应激的影响。本研究的目的是评估在美国陆军生存学校参加高强度军事训练的健康士兵的血浆NPY免疫反应性。陆军生存学校提供了一种观察个人在高水平的身体，环境和心理压力下的手段，因此被认为是战争或其他灾难性经历导致的压力的合理模拟。方法：在基线时评估血浆NPY水平（训练开始前），以及49名受试者生存训练结束后24小时，在基准线和战俘时期（P.O.W）经验（在接受军事审讯后立即）。结果：血浆神经肽Y水平显着增加相比，基线以下的审讯，并显着高于特种部队士兵，相比非特种部队士兵。讯问应激诱发的神经肽Y与被试的讯问行为显著相关，与报告分离症状呈负相关。生存训练结束后24小时，特种部队士兵的NPY已恢复到基线水平，但仍显着低于非特种部队士兵的基线值。应激状态下，NPY与皮质醇和行为表现呈正相关。NPY是负相关的精神症状dissociation.Conclusions：这些结果提供了证据表明，无法控制的压力显着增加血浆NPY在人类中，当延长，产生显着的血浆NPY耗尽。特种部队士兵与非特种部队士兵相比，应激引起的血浆NPY变化有显著差异。这些数据支持了这样一种观点，即NPY可能参与了人类增强的压力恢复能力。
Background: Neuropeptide-Y (NPY) is present in extensive neuronal systems of the brain and is present in high concentrations in cell bodies and terminals in the amygdala, Preclinical studies have shown that injections of NPY into the central nucleus of the amygdala function as a central anxiolytic and buffer against the effects of stress. The objective of this study was to assess plasma NPY immunoreactivity in healthy soldiers participating in high intensity military training at the U.S. Army survival school. The Army survival school provides a means of observing individuals under high levels of physical, environmental, and psychological stress, and consequently is considered a reasonable analogue to stress incurred as a result of war or other catastrophic experiences.Methods: Plasma levels of NPY were assessed at baseline (prior to initiation of training), and 24 hours after the conclusion of survival training in 49 subjects, and at baseline and during the Prisoner of War (P.O.W) experience (immediately after exposure to a military interrogation) in 21 additional subjects.Results: Plasma NPY levels were significantly increased compared to baseline following interrogations and were significantly higher in Special Forces soldiers, compared to non-Special Forces soldiers. NPY elicited by interrogation stress was significantly correlated to the subjects' behavior during interrogations and tended so be negatively correlated to symptoms of reported dissociation. Twenty-four hours after the conclusion of survival training, NPY had returned to baseline in Special Forces soldiers, but remained significantly lower than baseline values in non-Special Forces soldiers. NPY was positively correlated with both cortisol and behavioral performance under stress. NPY was negatively related to psychological symptoms of dissociation.Conclusions: These results provide evidence that uncontrollable stress significantly increases plasma NPY in humans, and when extended, produces a significant depletion of plasma NPY. Stress-induced alterations of plasma NPY were significantly different in Special Forces soldiers compared to non-Special Forces soldiers. These data support the idea that NPY may be involved in the enhanced stress resilience seen in humans.