Overexpression of HOXB9 promotes metastasis and indicates poor prognosis in colon cancer
Overexpression of HOXB9 promotes metastasis and indicates poor prognosis in colon cancer
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DOI：
10.3978/j.issn.1000-9604.2014.01.11
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发表时间：
2014-02-01
影响因子：
5.1
通讯作者：
Shao, Jianghua
中科院分区：
文献类型：
--
作者：
Huang, Kai;Yuan, Rongfa;Shao, Jianghua
目的：同源异型盒B9（HOXB 9）可能参与肿瘤血管生成和转移。方法：采用免疫组化和Western blotting方法检测128例结肠癌组织中HOXB 9的表达，并与临床病理资料和患者生存期进行统计学分析。结果：HOXB 9在结肠癌组织中过表达，并与结肠癌患者的转移和生存率显著相关（P
Objective: Homeobox B9 (HOXB9) is proposed to be involved in tumor angiogenesis and metastasis. We investigated the role of HOXB9 in the progression of colon cancer.Methods: HOXB9 expression was investigated by immunohistochemically and Western blotting in 128 colon cancer patients and the results were analyzed statistically associated with clinicopathological data and survival of the patients. The effect of HOXB9 on cell invasion and metastases abilities were analyzed in vitro and in vivo.Results: HOXB9 is overexpressed in colon cancer tissues and significantly correlated with metastasis and poor survival of patients (P