Comprehensive global genome dynamics of Chlamydia trachomatis show ancient diversification followed by contemporary mixing and recent lineage expansion.
Comprehensive global genome dynamics of Chlamydia trachomatis show ancient diversification followed by contemporary mixing and recent lineage expansion.
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DOI：
10.1101/gr.212647.116
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发表时间：
2017-07
期刊：
影响因子：
7
通讯作者：
Thomson NR
中科院分区：
文献类型：
--
作者：
Hadfield J;Harris SR;Seth-Smith HMB;Parmar S;Andersson P;Giffard PM;Schachter J;Moncada J;Ellison L;Vaulet MLG;Fermepin MR;Radebe F;Mendoza S;Ouburg S;Morré SA;Sachse K;Puolakkainen M;Korhonen SJ;Sonnex C;Wiggins R;Jalal H;Brunelli T;Casprini P;Pitt R;Ison C;Savicheva A;Shipitsyna E;Hadad R;Kari L;Burton MJ;Mabey D;Solomon AW;Lewis D;Marsh P;Unemo M;Clarke IN;Parkhill J;Thomson NR
沙眼衣原体是世界上最普遍的细菌性性传播感染和导致失明的主要传染性原因，但它是最不了解的人类病原体之一，部分原因是体外培养的困难和缺乏可用的遗传操作工具。基因组测序为这一领域注入了新的活力，揭示了这种病原体的当代历史。在这里，我们分析了563个完整的基因组，其中455个是新的，表明该物种的历史包括两个阶段，并得出结论，目前流通的谱系是在不同的基因组生态型进化的结果。时间分析表明，这些谱系最近在数千年的空间中扩展，而不是以前认为的数百万年，这一发现极大地改变了我们对这种病原体历史的理解。最后，在几乎所有病原体对抗菌剂的耐药性越来越强的时候，我们发现没有证据表明C.沙眼
Chlamydia trachomatis is the world's most prevalent bacterial sexually transmitted infection and leading infectious cause of blindness, yet it is one of the least understood human pathogens, in part due to the difficulties of in vitro culturing and the lack of available tools for genetic manipulation. Genome sequencing has reinvigorated this field, shedding light on the contemporary history of this pathogen. Here, we analyze 563 full genomes, 455 of which are novel, to show that the history of the species comprises two phases, and conclude that the currently circulating lineages are the result of evolution in different genomic ecotypes. Temporal analysis indicates these lineages have recently expanded in the space of thousands of years, rather than the millions of years as previously thought, a finding that dramatically changes our understanding of this pathogen's history. Finally, at a time when almost every pathogen is becoming increasingly resistant to antimicrobials, we show that there is no evidence of circulating genomic resistance in C. trachomatis.