Mechanical properties of highly porous PDLLA/Bioglass® composite foams as scaffolds for bone tissue engineering
Mechanical properties of highly porous PDLLA/Bioglass® composite foams as scaffolds for bone tissue engineering
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DOI：
10.1016/j.actbio.2005.07.003
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发表时间：
2005-11-01
影响因子：
9.7
通讯作者：
Nazhat, SN
中科院分区：
文献类型：
--
作者：
Blaker, JJ;Maquet, V;Nazhat, SN
这项研究开发了高度多孔的可降解复合材料作为骨组织工程的潜在支架。这些支架由聚-D,L-乳酸组成，填充有 2 和 15 vol.% 的 45S5 Bioglass (R) 颗粒，并通过热诱导固-液相分离和随后的溶剂升华生产。该支架具有双峰和各向异性的孔结构，具有直径接近100μm的管状大孔和直径接近10-50μm的互连微孔。使用压缩过程中进行的准静态和热动态力学分析以及热重分析来研究 Bioglasso (R) 对泡沫性能的影响。准静态压缩测试表明机械各向异性伴随着大孔的方向。应用分析建模方法，证明 Bioglass (R) 的存在不会显着改变这些泡沫的多孔结构，并反映了与扫描电子显微镜研究一致的机械各向异性。这项研究发现，Ishai-Cohen 和 Gibson-Ashby 模型可以结合起来预测复合泡沫的压缩模量。这些复杂泡沫的模量和密度与指数在 2 到 3 之间的幂律函数相关。(c) 2005 Acta Materialia Inc. 由 Elsevier Ltd 出版。保留所有权利。
This study developed highly porous degradable composites as potential scaffolds for bone tissue engineering. These scaffolds consisted of poly-D,L-lactic acid filled with 2 and 15 vol.% of 45S5 Bioglass (R) particles and were produced via thermally induced solid-liquid phase separation and subsequent solvent sublimation. The scaffolds had a bimodal and anisotropic pore structure, with tubular macro-pores of similar to 100 mu m in diameter, and with interconnected micro-pores of similar to 10-50 mu m in diameter. Quasi-static and thermal dynamic mechanical analysis carried out in compression along with thermogravimetric analysis was used to investigate the effect of Bioglasso (R) on the properties of the foams. Quasi-static compression testing demonstrated mechanical anisotropy concomitant with the direction of the macro-pores. An analytical modelling approach was applied, which demonstrated that the presence of Bioglass (R) did not significantly alter the porous architecture of these foams and reflected the mechanical anisotropy which was congruent with the scanning electron microscopy investigation. This study found that the Ishai-Cohen and Gibson-Ashby models can be combined to predict the compressive modulus of the composite foams. The modulus and density of these complex foams are related by a power-law function with an exponent between 2 and 3. (c) 2005 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.