A comparative study on the anti-inflammatory, antinociceptive and antipyretic effects of isoquinoline alkaloids from the roots of Turkish Berberis species
A comparative study on the anti-inflammatory, antinociceptive and antipyretic effects of isoquinoline alkaloids from the roots of Turkish Berberis species
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DOI：
10.1016/s0024-3205(02)02200-2
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发表时间：
2002-12-27
期刊：
影响因子：
6.1
通讯作者：
Baser, KHC
中科院分区：
文献类型：
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作者：
Küpeli, E;Kosar, M;Baser, KHC
根和树皮的各种Berespresso物种被用作民间补救措施，用于治疗各种炎症性疾病，如腰痛，风湿病和减少发烧。六异喹啉生物碱，即小檗碱，小檗胺，巴马汀，oxyacanthine，magnoflorine，和columbamine的分离作为主要成分，从土耳其小檗属植物的根和影响进行了研究，在小鼠体内模型中使用各种。所有生物碱在不同程度上抑制炎症，其中小檗碱，小檗胺和巴马汀被证明具有显着的和剂量依赖性的抑制活性，对马槟榔诱导的后爪水肿，无论是在口服和局部应用和乙酸诱导的血管通透性增加口服给药。此外，这三种生物碱也被证明具有剂量依赖性的镇痛活性，这是通过使用基于抑制对苯醌诱导的扭体运动以及亚急性给药对FCA诱导的直肠温度升高的解热活性的模型来评估的。然而，所有生物碱都引起不同程度的胃病变。(C)2002年爱思唯尔科学公司All rights reserved.
Roots and barks of various Berberis species are used as folk remedy for the treatment of various inflammatory diseases such as lumbago, rheumatism and to reduce fever. Six isoquinoline alkaloids namely berberine, berbamine, palmatine, oxyacanthine, magnoflorine, and columbamine were isolated as the main components of alkaloidal fraction from the roots of Turkish Berberis species and effects were studied using various in vivo models in mice. All alkaloids inhibited inflammations in varying degrees, among them berberine, berbamine and palmatine were shown to possess significant and dose-dependent inhibitory activity against serotonin-induced hind paw oedema both on oral and topical applications and acetic acid-induced increase in vascular permeability on oral administration. Moreover, these three alkaloids were also shown to possess dose-dependent antinociceptive activity, which assessed by using the model based on the inhibition of p-benzoquinone-induced writhing movements as well as antipyretic activity on FCA-induced increased rectal temperature on subacute administration. However, all alkaloids induced gastric lesions in varying degrees. (C) 2002 Elsevier Science Inc. All rights reserved.