Multidrug efflux transporters limit accumulation of inorganic, but not organic, mercury in sea urchin embryos.
Multidrug efflux transporters limit accumulation of inorganic, but not organic, mercury in sea urchin embryos.
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DOI：
10.1021/es901677r
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发表时间：
2009-11-01
影响因子：
11.4
通讯作者：
Hamdoun, Amro
中科院分区：
文献类型：
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作者：
Bosnjak, Ivana;Uhlinger, Kevin R.;Heim, Wesley;Smital, Tvrtko;Franekic-Colic, Jasna;Coale, Kenneth;Epel, David;Hamdoun, Amro
Mercuric compounds are persistent global pollutants that accumulate in marine organisms and in humans who consume them. While the chemical cycles and speciation of mercury in the oceans are relatively well described, the cellular mechanisms that govern which forms of mercury accumulate in cells and why they persist are less understood. In this study we examined the role of multidrug efflux transport in the differential accumulation of inorganic (HgCl2) and organic (CH3HgCl) mercury in sea urchin (Strongylocentrotus purpuratus) embryos. We found that inhibition of MRP/ABCC-type transporters increases intracellular accumulation of inorganic mercury but had no effect on accumulation of organic mercury. Similarly, pharmacological inhibition of metal conjugating enzymes by ligands GST/GSH significantly increases this antimitotic potency of inorganic mercury, but had no effect on the potency of organic mercury. Our results point to MRP-mediated elimination of inorganic mercury conjugates as a cellular basis for differences in the accumulation and potency of the two major forms of mercury found in marine environments.
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影响因子：
3.8
作者：
Bridges, Christy C.;Joshee, Lucy;Zalups, Rudolfs K.
通讯作者：
Zalups, Rudolfs K.
影响因子：
3.5
作者：
Kim, SH;Bark, H;Choi, CH
通讯作者：
Choi, CH
DOI：
10.1016/0272-0590(85)90165-4
发表时间：
1985-01-01
期刊：
FUNDAMENTAL AND APPLIED TOXICOLOGY
影响因子：
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作者：
BALLATORI, N;CLARKSON, TW
通讯作者：
CLARKSON, TW
影响因子：
11.4
作者：
Epel, David;Luckenbach, Till;Smital, Tvrtko
通讯作者：
Smital, Tvrtko
影响因子：
10.4
作者：
通讯作者：
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