Adhesion of Candida Albicans to Host Surfaces
Adhesion of Candida Albicans to Host Surfaces
复制标题
白色念珠菌对宿主表面的粘附
DOI：
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发表时间：
1991
期刊：
影响因子：
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通讯作者：
L. Douglas
中科院分区：
文献类型：
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作者：
L. Douglas
致病念珠菌在宿主表面的定殖取决于真菌的粘附能力。附着力使生物体能够抵抗持续冲洗这些表面的流体的冲洗作用。在粘膜表面的情况下，具有粘附微生物的上皮细胞由于脱落而反复丢失，因此如果要继续定植，这些生物体的后代会附着在新暴露的细胞上。这种宿主防御机制提供了一种选择性压力，可能导致消除粘附性较低的生物体。因此，粘附是导致持续定殖和感染的过程中的第一步，并且粘附能力构成重要的毒力因子。
Colonization of host surfaces by the pathogenic Candida species depends on the ability of the fungi to adhere. Adhesion enables the organisms to resist the flushing action of the fluids that continuously bathe such surfaces. In the case of mucosal surfaces, epithelial cells with adherent microorganisms are repeatedly lost by desquamation and so the progeny of these organisms much attach to newly exposed cells if colonization is to continue. This host defence mechanism provides a selective pressure which may result in the elimination of less adhesive organisms. Adhesion is, therefore, the first step in the process leading to persistent colonization and infection, and the ability to adhere constitutes an important virulence factor.