A study to evaluate herb-drug interaction underlying mechanisms: An investigation of ginsenosides attenuating the effect of warfarin on cardiovascular diseases
A study to evaluate herb-drug interaction underlying mechanisms: An investigation of ginsenosides attenuating the effect of warfarin on cardiovascular diseases
复制标题
评估草药与药物相互作用潜在机制的研究：人参皂苷减弱华法林对心血管疾病影响的研究
DOI：
10.1016/j.ejps.2019.105100
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发表时间：
2020-01-15
影响因子：
4.6
通讯作者：
Shao, Jing-Wei
中科院分区：
文献类型：
--
作者：
Lin, Juan-Fang;Fan, Lu-Lu;Shao, Jing-Wei
黄芪和人参已被广泛用于治疗心血管疾病。然而，中药联合治疗的临床安全性和有效性仍存在争议。因此，研究人参与华法林的相互作用是十分必要的。本研究通过体外和体内研究，探讨人参主要成分人参皂苷（GS）与华法林之间是否存在相互作用。体外研究表明，与华法林/GS单独处理相比，华法林+ GS联合处理可上调内皮细胞间粘附分子（ICAM-1）和血管细胞粘附分子（VCAM-1）蛋白的表达，从而增强内皮细胞与基质胶/血小板的粘附能力。此外，GS可通过增加华法林与GS长期联合给药后血浆中凝血因子和肝细胞色素P450酶的表达水平而减弱华法林对高脂血症大鼠的抗凝作用。体内外研究结果表明，华法林与人参之间存在严重的相互作用，二者联合应用后，可加重动脉粥样硬化和血栓形成。
Warfarin and ginseng have been widely used in the treatment of cardiovascular diseases. However, the clinical safety and effectiveness of herb-drug combination treatment are still controversial. Therefore, it is very essential to probe the interaction between warfarin and ginseng. In this study, in vitro and in vivo study was carried out to demonstrate that whether there is an interaction between warfarin and ginsenosides (GS), which is the main component of ginseng. In vitro study showed that the adhesion ability between endothelial cells and matrigel/platelets was enhanced due to the up-regulating expression of intercellular adhesion molecule (ICAM-1) and vascular cell adhesion molecule (VCAM-1) proteins by treatment of warfarin + GS combination compared to warfarin/GS treatment alone. Moreover, GS could weaken the anticoagulation effect of warfarin in hyperlipemia rats owning to the increased expression levels of coagulation factors and hepatic cytochrome P450 enzymes in plasma after long-term co-administration of warfarin with GS. The results of both in vitro and in vivo study demonstrated that there is a serious interaction between warfarin and ginseng, which may deteriorate atherosclerosis and thrombosis after combined use of warfarin and GS.