Effects of zinc coadministration on lead toxicities in rats.
Effects of zinc coadministration on lead toxicities in rats.
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DOI：
10.2486/indhealth.45.546
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发表时间：
2007-08
影响因子：
2
通讯作者：
F. Piao;F. Cheng;Haibo Chen;Gang Li;Xiance Sun;Shuang Liu;T. Yamauchi;K. Yokoyama
中科院分区：
文献类型：
--
作者：
F. Piao;F. Cheng;Haibo Chen;Gang Li;Xiance Sun;Shuang Liu;T. Yamauchi;K. Yokoyama
为了研究锌对铅毒性的影响。检测精子畸形率、微核率、血清甲状腺激素（T3、T4）、皮质醇。腹腔注射醋酸铅25 mg/kg、醋酸锌4 mg/kg、醋酸铅和醋酸锌同时注射、生理盐水对照，隔日1次，共7次。全血铅无显着差异检测组之间的铅单独或铅和锌。与此相反，全血锌浓度在组单独给予锌显着高于组，铅和锌。结果表明，铅组和铅锌组精子畸形率、MPCE频率和血清皮质醇水平均显著高于对照组，而血清T3和T4水平显著低于对照组。在同时给予铅和锌的组中，四组中T（4）下降最明显。铅锌联合染毒组精子畸形率低于铅单独染毒组。结果表明，锌联合给药可减轻铅对雄性生殖系统的毒性作用，但可增强铅对甲状腺功能的毒性作用。锌没有影响铅对细胞遗传学系统的毒性所示的MPCE百分比，并在本研究的剂量下对血清皮质醇水平。结果表明，Zn对Pb在不同器官中毒性的影响具有“双刃效应”。因此，应系统评价锌对铅毒性的影响。
In order to investigate the effects of Zn on Pb toxicities. Proportion of abnormal sperm, percentage of micronucleated polychromatic erythrocyte (MPCE), serum thyroid hormones (T(3), T(4)) and cortisol were measured. Rats received intraperitoneal injection of 25 mg/kg Pb acetate, 4 mg/kg Zn acetate, both Pb acetate and Zn acetate, or normal saline as controls, once every two days, 7 times in total. No significant differences in whole blood Pb were detected between groups received Pb alone or both Pb and Zn. On the contrary, the concentration of whole blood Zn in the group given Zn alone was significantly higher than that in the group that received both Pb and Zn. In the groups given Pb alone or both Pb and Zn, proportion of abnormal sperm, frequency of MPCE and serum cortisol were significantly higher than those in controls, whereas serum T(3) and T(4) were significantly lower than in controls. In the group given both Pb and Zn, T(4) was decreased most obviously among the four groups. While the proportion of abnormal sperm was less in the group given both Pb and Zn than in the group given Pb alone. These findings suggest that Zn coadministration might alleviate toxic effects of Pb on the male reproductive system, whereas it could enhance the toxicity on thyroid function. Zn did not affect the toxicities of Pb on cytogenetic systems as indicated by MPCE percentage, and on serum cortisol levels under the dose of the present study. Our results suggested the double-edged effects of Zn on Pb toxicities in different organs. Therefore, the effects of Zn on Pb toxicities should be evaluated systematically.