Histamine regulation of innate and adaptive immunity
Histamine regulation of innate and adaptive immunity
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DOI：
10.2741/3914
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发表时间：
2012-01-01
影响因子：
3.1
通讯作者：
O'Mahony, Liam
中科院分区：
文献类型：
--
作者：
Ferstl, Ruth;Akdis, Cezmi A.;O'Mahony, Liam
组胺影响许多参与先天性和适应性免疫反应调节的细胞类型，包括抗原呈递细胞 (APC)、自然杀伤 (NK) 细胞、上皮细胞、T 淋巴细胞和 B 淋巴细胞。这些细胞表达组胺受体（HR）并分泌组胺，组胺可以选择性地将主要效应细胞募集到组织部位并影响其成熟、激活、极化和效应功能，从而导致耐受性或促炎症反应。组胺及其四种受体代表了一个复杂的免疫调节系统，受体亚型及其差异表达具有不同的影响，其根据细胞分化阶段和微环境影响而变化。在这篇综述中，我们讨论了先天性和适应性免疫反应中组胺受体的表达和细胞的差异激活，以及影响其活性的信号转导机制。
Histamine influences many cell types involved in the regulation of innate and adaptive immune responses including antigen-presenting cells (APCs), Natural Killer (NK) cells, epithelial cells, T lymphocytes and B lymphocytes. These cells express histamine receptors (HRs) and also secrete histamine, which can selectively recruit the major effector cells into tissue sites and affect their maturation, activation, polarization and effector functions leading to tolerogenic or pro-inflammatory responses. Histamine and its four receptors represent a complex system of immunoregulation with distinct effects of receptor subtypes and their differential expression, which changes according to the stage of cell differentiation as well as micro-environmental influences. In this review, we discuss histamine receptor expression and differential activation of cells within both the innate and adaptive immune response and the signal transduction mechanisms which influence their activity.