Central and peripheral circadian clocks and their role in Alzheimer's disease.
Central and peripheral circadian clocks and their role in Alzheimer's disease.
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DOI：
10.1242/dmm.030627
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发表时间：
2017-10-01
影响因子：
4.3
通讯作者：
Crowther DC
中科院分区：
文献类型：
--
作者：
Chauhan R;Chen KF;Kent BA;Crowther DC
分子和细胞振荡构成了一个内部时钟，它跟踪一天中的时间，并允许生物体优化其行为和新陈代谢，以适应他们面临的日常需求。随着年龄的增长，这种内部时钟的工作受到损害。在这篇综述中，我们讨论了这种与年龄相关的生物钟损伤是否与年龄相关的神经退行性疾病，如阿尔茨海默病相互作用。小鼠和果蝇阿尔茨海默病模型的发现加速了我们对神经退行性疾病和昼夜节律生物学之间相互作用的理解。这些模型表明，神经退行性变可能通过损害中枢时钟或阻断其与其他大脑区域和外周组织的通信来损害昼夜节律。随之而来的睡眠和代谢缺陷可能会增强大脑对进一步退化过程的敏感性。因此，昼夜节律功能障碍可能是神经退行性变的原因和结果。我们还讨论了光在中央时钟夹带的主要作用，并描述了重要的，替代的时间信号，如食物，在夹带中央和外周生物钟中发挥作用。最后，我们提出了这些最新的见解如何为开发新的治疗方法以重新吸引患有神经退行性疾病的痴呆患者提供信息。总结：这篇综述总结了果蝇和小鼠模型的研究如何加速我们对昼夜节律功能障碍与年龄相关的神经退行性疾病，特别是阿尔茨海默病之间联系的理解。
Molecular and cellular oscillations constitute an internal clock that tracks the time of day and permits organisms to optimize their behaviour and metabolism to suit the daily demands they face. The workings of this internal clock become impaired with age. In this review, we discuss whether such age-related impairments in the circadian clock interact with age-related neurodegenerative disorders, such as Alzheimer's disease. Findings from mouse and fly models of Alzheimer's disease have accelerated our understanding of the interaction between neurodegeneration and circadian biology. These models show that neurodegeneration likely impairs circadian rhythms either by damaging the central clock or by blocking its communication with other brain areas and with peripheral tissues. The consequent sleep and metabolic deficits could enhance the susceptibility of the brain to further degenerative processes. Thus, circadian dysfunction might be both a cause and an effect of neurodegeneration. We also discuss the primary role of light in the entrainment of the central clock and describe important, alternative time signals, such as food, that play a role in entraining central and peripheral circadian clocks. Finally, we propose how these recent insights could inform efforts to develop novel therapeutic approaches to re-entrain arrhythmic individuals with neurodegenerative disease. Summary: This Review summarizes how studies in Drosophila and mouse models accelerate our understanding of the links between circadian rhythm dysfunctions and age-related neurodegenerative disorders, especially Alzheimer's disease.
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影响因子：
168.9
作者：
Ballard, Clive;Gauthier, Serge;Jones, Emma
通讯作者：
Jones, Emma
淀粉样蛋白β动力学与受伤的人脑中的神经系统状况相关。
影响因子：
56.9
作者：
Brody, David L.;Magnoni, Sandra;Schwetye, Kate E.;Spinner, Michael L.;Esparza, Thomas J.;Stocchetti, Nino;Zipfel, Gregory J.;Holtzman, David M.
通讯作者：
Holtzman, David M.
DOI：
10.1111/j.1532-5415.1992.tb01849.x
发表时间：
1992-08-01
影响因子：
6.3
作者：
BUYSSE, DJ;BROWMAN, KE;KUPFER, DJ
通讯作者：
KUPFER, DJ
影响因子：
3
作者：
Carneiro BT;Araujo JF
通讯作者：
Araujo JF
影响因子：
5.6
作者：
Benedict, Christian;Cedernaes, Jonathan;Schioth, Helgi B.
通讯作者：
Schioth, Helgi B.