PLACENTAL PROTEIN-4 AS A POSSIBLE TUMOR-MARKER IN OVARIAN-TUMORS
PLACENTAL PROTEIN-4 AS A POSSIBLE TUMOR-MARKER IN OVARIAN-TUMORS
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DOI：
10.1159/000293006
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发表时间：
1991-01-01
影响因子：
2.1
通讯作者：
BOHN, H
中科院分区：
文献类型：
--
作者：
GOCZE, PM;SZABO, DG;BOHN, H
Placental protein 4 (PP-4), a recently characterized glycoprotein from human placenta, was studied using a specific double-antibody radioimmunoassay in sera of 130 volunteers, 76 ovarian tumor patients and in ovarian tumor cyst fluid and ascites of 21 patients. Elevated levels (> 3-mu-g/l) were found in 45 of 52 ovarian cancer patients (86.5%). PP-4 levels correlated significantly with staging. 31 patients with malignant ovarian tumor were monitored on 2-9 occasions during 5-82 weeks. Rising or falling levels of PP-4 correlated with progression or regression of disease in 25 of 31 instances (80.6%). Elevated levels were found in 10 of 24 benign and borderline ovarian tumors. Elevated PP-4 level does not indicate malignancy in each case. PP-4 can be regarded as tumor-associated antigen and a tumor marker in oncological practice.
