The tumor suppressive role of inhibin A in diffuse large B-cell lymphoma
The tumor suppressive role of inhibin A in diffuse large B-cell lymphoma
复制标题
抑制素βA在弥漫性大B细胞淋巴瘤中的肿瘤抑制作用
DOI：
10.1080/10428194.2017.1372574
复制
发表时间：
2018-01-01
影响因子：
2.6
通讯作者：
Zhou, Jeff X.
中科院分区：
文献类型：
--
作者：
Jiang, Lei;Si, Ting;Zhou, Jeff X.
INHBA（抑制素A）是转化生长因子超家族配体的一个亚基，已知在各种实体瘤中发挥多种作用。然而，其在血液系统恶性肿瘤中的作用仍未探索。在这里，我们研究了INHBA在弥漫性大B细胞淋巴瘤（DLBCL）中的功能。与良性扁桃体相比，无论是生发中心B细胞样（GCB）还是非GCB亚型，原发性DLBCL组织中INHBA的mRNA和蛋白水平均显著下调。原发DLBCL患者中INHBA水平较低与总生存期和无进展生存期降低相关。INHBA在DLBCL细胞系（OCI-Ly 01和SUDHL-10）中的异位表达导致细胞增殖降低、自发凋亡增加和体外细胞周期停滞，并抑制体内异种移植肿瘤生长。此外，INHBA增强DLBCL细胞的化疗敏感性。因此，我们的研究结果提供了新的证据，INHBA作为一个肿瘤抑制DLBCL的功能。
INHBA (inhibin A), a subunit of a ligand of the transforming growth factor- superfamily, is known to play diverse roles in various solid tumors. However, its role in hematologic malignancies remains unexplored. Here, we investigated the function of INHBA in diffuse large B-cell lymphoma (DLBCL). Both mRNA and protein levels of INHBA were significantly downregulated in primary DLBCL tissues, irrespective of germinal center B-cell-like (GCB) or non-GCB subtype, compared to those in benign tonsils. The low level of INHBA in patients with de novo DLBCL was correlated with reduced overall and progression-free survival. Ectopic expression of INHBA in DLBCL cell lines (OCI-Ly01 and SUDHL-10) resulted in reduced cell proliferation, increased spontaneous apoptosis and arrested cell cycle in vitro and suppressed xenograft tumor growth in vivo. Moreover, INHBA enhanced the chemosensitivity of DLBCL cells. Thus, our results provide novel evidence that INHBA functions as a tumor suppressor in DLBCL.