Transfer insensitive labeling technique (TILT): Application to multislice functional perfusion imaging
Transfer insensitive labeling technique (TILT): Application to multislice functional perfusion imaging
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DOI：
10.1002/(sici)1522-2586(199903)9:3
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发表时间：
1999-03
影响因子：
4.4
通讯作者：
X. Golay;M. Stuber;K. Pruessmann;D. Meier;P. Boesiger
中科院分区：
文献类型：
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作者：
X. Golay;M. Stuber;K. Pruessmann;D. Meier;P. Boesiger
脑血流可以在多层模式下进行研究，最近提出的灌注序列使用水自旋反转作为内源性示踪剂，没有磁化转移伪影。磁化转移不敏感标记技术（TILT）已被用于在多层模式下在运动激活下在微血管水平映射血流变化。在TILT中，灌注标测通过从对照图像中减去灌注敏感图像来实现。灌注加权通过使用两个90°射频激励脉冲的近端血液标记来完成。对于对照制备，修改标记脉冲，使得它们对血液水磁化没有净效应。血流变化的百分比，以及它的空间范围，已经在单层和多层模式下进行了研究，在标记和成像之间具有不同的延迟。在单层实验中，由于激活引起的平均灌注信号变化为36.9 ± 9.1%，在多层实验中为38.1 ± 7.9%。激活的脑区体积在对侧初级运动（M1）区为1.51 ± 0.95 cm 3，在同侧M1区为0.90 ± 0.72 cc，在对侧为1.27 ± 0.39 cm 3，在同侧运动前区为1.42 ± 0.75 cm 3，辅助运动区为0.71 ± 0.19cm ~ 3。Imaging 1999;9：454-461.© 1999 Wiley利斯公司
Cerebral blood flow can be studied in a multislice mode with a recently proposed perfusion sequence using inversion of water spins as an endogenous tracer without magnetization transfer artifacts. The magnetization transfer insensitive labeling technique (TILT) has been used for mapping blood flow changes at a microvascular level under motor activation in a multislice mode. In TILT, perfusion mapping is achieved by subtraction of a perfusion‐sensitized image from a control image. Perfusion weighting is accomplished by proximal blood labeling using two 90° radiofrequency excitation pulses. For control preparation the labeling pulses are modified such that they have no net effect on blood water magnetization. The percentage of blood flow change, as well as its spatial extent, has been studied in single and multislice modes with varying delays between labeling and imaging. The average perfusion signal change due to activation was 36.9 ± 9.1% in the single‐slice experiments and 38.1 ± 7.9% in the multislice experiments. The volume of activated brain areas amounted to 1.51 ± 0.95 cm3 in the contralateral primary motor (M1) area, 0.90 ± 0.72 cc in the ipsilateral M1 area, 1.27 ± 0.39 cm3 in the contralateral and 1.42 ± 0.75 cm3 in the ipsilateral premotor areas, and 0.71 ± 0.19 cm3 in the supplementary motor area.J. Magn. Reson. Imaging 1999;9:454–461. © 1999 Wiley‐Liss, Inc.