Simultaneous ultrasound measurement of articular cartilage and subchondral bone
Simultaneous ultrasound measurement of articular cartilage and subchondral bone
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DOI：
10.1016/j.joca.2010.09.009
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发表时间：
2010-12-01
影响因子：
7
通讯作者：
Jurvelin, J. S.
中科院分区：
文献类型：
--
作者：
Aula, A. S.;Toyras, J.;Jurvelin, J. S.
目的：骨关节炎（OA）是软骨退变过程中发生的软骨下硬化。高频超声（12-55 MHz）已被证明可以诊断退化的关节软骨，而0.1-1 MHz超声已被应用于骨的临床表征和骨质疏松症的诊断。本研究的目的是调查，第一次，5 MHz超声的可行性，同时分析关节软骨和subchonelybone.Methods：Osteochonelyte样品（n = 10），从新鲜和视觉正常的牛胫骨内侧plataeus。结果：软骨内的表观背向散射积分（AIB）与羟脯氨酸（Hypro）呈显著的偏相关（r = 0.58，P = 0.000），软骨内的AIB与羟脯氨酸（Hypro）呈显著的偏相关（r = 0.58，P = 0.000）。组织含水量（r =-0.52，P = 0.001）和动态模量（r = 0.57，P = 0.000）。骨AIB与软骨下骨密度呈弱相关（r =-0.34，P = 0.041）。软骨厚度的地形变化可以使用超声检测。软骨的组成、厚度和机械性能在胫骨平台上有显著差异。对于计算的超声参数，变化是显着的只有少数location.Conclusions之间：脉冲回波超声几何在5 MHz的同时测量关节软骨和软骨下骨的声学特性是可行的。然而，超声参数与软骨和骨的性质之间的关系并不像早期仅关注骨或软骨的研究中报道的那样强。由于关节面的自然曲率，同时测量两种组织会影响超声脉冲入射的精确度。显然，这种来源的不确定性应尽量减少，以使有效的临床使用的超声同时测量关节软骨和软骨下骨。(C)2010年国际骨关节炎研究学会。由爱思唯尔有限公司出版。保留所有权利。
Objective: In osteoarthritis (OA), subchondral sclerosis takes place during cartilage degeneration. High frequency ultrasound (12-55 MHz) has been shown to diagnose degenerated articular cartilage, while 0.1-1 MHz ultrasound has been applied for clinical characterization of bone and diagnostics of osteoporosis. The aim of the study is to investigate, for the first time, the feasibility of 5 MHz ultrasound for simultaneous analysis of articular cartilage and subchondral bone.Methods: Osteochondral samples (n = 10) were prepared from fresh and visually normal bovine medial tibial plateaus. Acoustic properties of the cartilage and subchondral bone were measured with a scanning ultrasound system using the pulse-echo geometry and compared with biomechanical, histological and compositional reference data.Results: The apparent integrated backscatter (AIB) from internal cartilage showed significant partial correlations with hydroxyproline (Hypro) (r = 0.58, P = 0.000). water content (r = -0.52, P = 0.001) and dynamic modulus (r = 0.57, P = 0.000) of the tissue. Weak but statistically significant correlation was found between the bone AIB and mineral density of the subchondral plate (r = -0.34, P = 0.041). Topographical variations in cartilage thickness could be detected using ultrasound. Composition, thickness and mechanical properties of the cartilage varied significantly across the tibial plateau. For the calculated ultrasound parameters, the variation was significant only between a few locations.Conclusions: Pulse-echo ultrasound geometry at 5 MHz was feasible for simultaneous measurement of the acoustic properties of articular cartilage and subchondral bone. However, the relationships between the ultrasound parameters and properties of cartilage and bone were not as strong as reported earlier in studies focusing only either on bone or cartilage. Simultaneous measurement of both tissues compromises, due to natural curvature of articulating surfaces, the perpendicularity of the incidence of the ultrasound pulse. Obviously, this source of uncertainty should be minimized in order to enable effective clinical use of ultrasound in simultaneous measurement of articular cartilage and subchondral bone. (C) 2010 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.