Characterization of cardiac bradyarrhythmia associated with LGI1-IgG autoimmune encephalitis.
Characterization of cardiac bradyarrhythmia associated with LGI1-IgG autoimmune encephalitis.
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DOI：
10.3389/fimmu.2022.948479
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发表时间：
2022
影响因子：
7.3
通讯作者：
Dubey, Divyanshu
中科院分区：
文献类型：
--
作者：
Zhao-Fleming, Hannah H.;Zahid, Anza;Lu, Tong;Sun, Xiaojing;Pittock, Sean J.;Lee, Hon-Chi;Dubey, Divyanshu
评价和描述与LGI 1-IgG（富含亮氨酸的胶质瘤灭活1-IgG）自身免疫性脑炎（AE）相关的心律失常。在这项回顾性描述性研究中，我们确定了马约诊所（2008年5月1日至2020年12月31日）发生LGI 1-IgG AE的患者，这些患者在首次就诊时心电图证实为缓慢性心律失常。入选标准为1）LGI 1-IgG阳性伴一致的临床综合征; 2）心动过缓的心电图证据; 3）充分的临床详情。我们排除了在缓慢性心律失常时正在服用负离子药物的患者。我们收集了人口统计学/临床数据，包括缓慢性心律失常的详细信息（严重程度、持续时间、治疗）以及神经和心脏结局。我们发现，LGI 1-IgG AE患者在最初的介绍中发生缓慢性心律失常的频率为8%。缓慢性心律失常通常无症状（6/11，55%）;然而，事件严重，1例患者需要起搏器。结局通常也是有利的，大多数（8/11，73%）在没有进一步心脏干预的情况下完全消退。最后，我们发现小鼠和人类心脏组织表达LGI 1（mRNA和蛋白质）。LGI 1-IgG AE很少与缓慢性心律失常相关。虽然病程大多是有利的，但有些病例可能需要放置起搏器以避免破坏性结局。
To evaluate and characterize cardiac arrythmias associated with LGI1-IgG (Leucine-rich glioma inactivated 1–IgG) autoimmune encephalitis (AE). In this retrospective descriptive study, we identified Mayo Clinic patients (May 1, 2008 – December 31, 2020) with LGI1-IgG AE who had electrocardiogram proven bradyarrhythmias during the initial presentation. Inclusion criteria were 1) LGI1-IgG positivity with a consistent clinical syndrome; 2) electrocardiographic evidence of bradyarrhythmia; and 3) sufficient clinical details. We excluded patients who were taking negative ionotropic agents at the time of their bradyarrhythmias. We collected demographic/clinical data including details of bradyarrhythmia (severity, duration, treatments), and neurologic and cardiac outcomes. We found that patients with LGI1-IgG AE had bradyarrhythmia at a frequency of 8% during the initial presentation. The bradyarrhythmia was often asymptomatic (6/11, 55%); however, the episode was severe with one patient requiring a pacemaker. Outcome was also generally favorable with the majority (8/11, 73%) having full resolution without further cardiac intervention. Lastly, we found that mouse and human cardiac tissues express LGI1 (mRNA and protein). LGI1-IgG AE can be rarely associated with bradyarrhythmias. Although the disease course is mostly favorable, some cases may require pacemaker placement to avoid devastating outcomes.
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影响因子：
29
作者：
Naasan, Georges;Irani, Sarosh R.;Bettcher, Brianne M.;Geschwind, Michael D.;Gelfand, Jeffrey M.
通讯作者：
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影响因子：
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作者：
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通讯作者：
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作者：
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通讯作者：
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