Platelet von Willebrand's Antigen II: Active Release by Aggregating Agents and a Marker of Platelet Release Reaction In Vivo
Platelet von Willebrand's Antigen II: Active Release by Aggregating Agents and a Marker of Platelet Release Reaction In Vivo
复制标题
血小板血管性血友病抗原 II：聚集剂的主动释放和体内血小板释放反应的标志物
DOI：
10.1182/blood.v58.6.1075.bloodjournal5861075
复制
发表时间：
1981
期刊：
影响因子：
20.3
通讯作者：
R. Montgomery
中科院分区：
文献类型：
--
作者：
J. Scott;R. Montgomery
在血管性血友病中，血管性血友病抗原II（vW Ag II），一种在免疫学和生物化学上不同于因子VIII相关抗原（VIIIR：Ag）的血浆和血小板抗原，减少。vW AgII在聚集和凝血期间从血小板释放。血小板vW AgII的释放进行了研究，在洗涤后的血小板聚集凝血酶，胶原蛋白，和腺苷二磷酸（ADP）。总血小板vW AgII为3.39 U/10（9）个血小板。凝血酶和胶原蛋白分别释放85%和86%的血小板vW AgII，在最高浓度。血小板vW AgII的释放与5-羟色胺（5-HT）的释放相关。胶原和凝血酶释放的vW AgII被代谢抑制剂抑制。此外，阿司匹林可抑制vW AgII的胶原释放。在与血管内血小板破坏相关的临床综合征中，注意到血浆vW AgII显著升高。因此，vW AgII在血小板聚集期间通过代谢活性过程从血小板释放。此外，vW AgII似乎是血管内血小板破坏的标志物。
von Willebrand's antigen II (vW AgII), a plasma and platelet antigen immunologically and biochemically distinct from factor-VIII-related antigen (VIIIR:Ag), is decreased in von Willebrand's disease. vW AgII is released from platelets during aggregation and clotting. The release of platelet vW AgII was studied in washed platelets following aggregation by thrombin, collagen, and adenosine diphosphate (ADP). Total platelet vW AgII was 3.39 U/10(9) platelets. Thrombin and collagen yielded release of 85% and 86% of platelet vW AgII, respectively, at the highest concentrations. Release of platelet vW AgII was correlated with the release of 5-hydroxytryptamine (5HT). Release of vW AgII by collagen and thrombin was inhibited by metabolic inhibitors. In addition, collagen release of vW AgII was inhibited by aspirin. In clinical syndromes associated with intravascular platelet destruction, marked elevations of plasma vW AgII were noted. Thus, vW AgII is released by a metabolically active process from platelets during aggregation. In addition, vW AgII appears to be a marker of intravascular platelet destruction.