Serum Matrix Metalloproteinase-9 Is Associated With Depression After Acute Ischemic Stroke
Serum Matrix Metalloproteinase-9 Is Associated With Depression After Acute Ischemic Stroke
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血清基质金属蛋白酶 9 与急性缺血性中风后抑郁症相关
DOI：
10.1253/circj.cj-19-0376
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发表时间：
2019-11-01
影响因子：
3.3
通讯作者：
He, Jiang
中科院分区：
文献类型：
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作者：
Che, Bizhong;Zhong, Chongke;He, Jiang
背景资料：基质金属蛋白酶-9（MMP-9）是细胞外基质降解的关键因子，可能导致脑卒中后脑损伤，并参与抑郁症状的发生。本研究旨在探讨血清MMP-9水平与脑卒中后抑郁（post-stroke depression，PSD）的关系。方法和结果：对中国急性缺血性脑卒中降压试验（China Antihypertensive Trial in Acute Ischemic Stroke）7家医院的558例急性缺血性脑卒中患者进行血清MMP-9水平测定。我们使用24项汉密尔顿抑郁评定量表评估抑郁状态，并将PSD定义为8分的临界值。Logistic回归分析估计PSD与血清MMP-9相关的风险。分析MMP-9对PSD的鉴别和分型。共有222例（39.8%）卒中患者在3个月内被归类为PSD。PSD患者的血清MMP-9浓度高于无PSD患者（658.8 vs 485.7 ng/mL; P
Background: Matrix metalloproteinase-9 (MMP-9), a key determinant of extracellular matrix degradation, might cause cerebral damage after stroke and be involved in the development of depressive symptoms. This study aimed to evaluate the association of serum MMP-9 levels and post-stroke depression (PSD).Methods and Results: Serum MMP-9 levels were determined in 558 acute ischemic stroke patients from 7 hospitals comprising the China Antihypertensive Trial in Acute Ischemic Stroke. We assessed depression status using the 24-item Hamilton Depression Rating Scale and defined PSD as a cutoff score of 8. Logistic regression was performed to estimate the risk of PSD associated with serum MMP-9. Discrimination and reclassification for PSD by MMP-9 were analyzed. A total of 222 (39.8%) stroke patients were categorized as PSD within 3 months. Serum MMP-9 concentrations were higher among PSD patients than those without PSD (658.8 vs. 485.7 ng/mL; P