S-cone, L+M-cone, and pattern, electroretinograms in ocular hypertension and glaucoma
S-cone, L+M-cone, and pattern, electroretinograms in ocular hypertension and glaucoma
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DOI：
10.1016/j.visres.2004.06.015
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发表时间：
2004-11-01
期刊：
影响因子：
1.8
通讯作者：
North, RV
中科院分区：
文献类型：
--
作者：
Aldebasi, YH;Drasdo, N;North, RV
采用无声替代和选择性适应技术，对18例高眼压症（OHT）、9例正常眼压性青光眼（NTG）、18例早期原发性开角型青光眼（POAG）和19例正常对照者进行了全视野S锥和L + M锥视网膜电图检查。还记录了图形视网膜电图，使用减小的检查尺寸以增加视网膜神经节细胞的贡献。在OHT和POAG组中，与对照组相比，观察到所有三种类型的ERG的振幅的统计学显著降低（P = 0.05-0.001），最显著的是在晚期负波中。这些被认为反映了神经节细胞的活动。结果表明，在OHT和早期POAG中，弥漫性分布的活性丧失（20-35%）对许多视网膜通路的影响程度相似，
Silent substitution and selective adaptation techniques were used to obtain full field S-cone and L + M-cone electroretinograms from 18 patients with ocular hypertension (OHT), 9 with normotensive glaucoma (NTG), 18 with early primary open angle glaucoma (POAG) and 19 normal controls. Pattern electroretinograms were also recorded, using a reduced check size to increase the contribution of retinal ganglion cells. In the OHT and POAG groups, statistically significant reductions (P = 0.05-0.001) were observed in the amplitudes, most notably in the late negative waves of all three types of ERG compared to the controls. These are thought to reflect ganglion cell activity. The results imply a diffusely distributed loss of activity (20-35%) affecting many retinal pathways to a similar extent in OHT and early POAG, with an additional amount (