THE STEIN-LEVENTHAL SYNDROME - ANALYSIS OF 43 CASES WITH SPECIAL REFERENCE TO ASSOCIATION WITH ENDOMETRIAL CARCINOMA
THE STEIN-LEVENTHAL SYNDROME - ANALYSIS OF 43 CASES WITH SPECIAL REFERENCE TO ASSOCIATION WITH ENDOMETRIAL CARCINOMA
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DOI：
10.1016/s0002-9378(16)37277-5
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发表时间：
1957-01-01
影响因子：
9.8
通讯作者：
DOCKERTY, MB
中科院分区：
文献类型：
--
作者：
JACKSON, RL;DOCKERTY, MB
A study has been made at the Mayo Clinic of the clinical and pathologic data on 43 patients who had the Stein-Leventhal syndrome. The majority of these patients were obese, excessively hairy, hypertensive, and infertile. Menstrual irregularities featuring a high incidence of amenorrhea were extremely common. These patients were seen between 1909 and 1954, inclusive. Of the 43 patients, 16 patients, who are placed in the neoplastic group, had uterine carcinoma. Ages in the 27 patients in the nonneoplastic group varied from 17 to 42 years. Characteristic ovarian changes consisted of bilateral enlargement, thick cortical rinds, and polycystic cortices. The cysts represented maturing follicles that were tense with fluid and lined by granulosa cells. The surrounding theca was hyperplastic and sometimes fatty. Numerous primordial ova and follicles were usually apparent. The central portions of the ovaries were tough and fibrous. Corpora lutea were nearly always absent.The principal type of treatment employed in these 27 patients was surgical. In 19 patients, this consisted of removal of bilateral ovarian wedges designed to include the thickening tunica and a generous portion of the deeper ovarian stroma. One of these 19 patients also had a plastic procedure done on the left tube. Two of the remaining eight patients underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy because of associated fibroids. One patient had resection of her one “remaining” ovary. One patient, who was also suffering from associated pelvic tuberculosis, had bilateral salpingooophorectomy. Four patients, seen many years ago, underwent bilateral oophorectomy. Ancillary therapy given in two instances included preoperative use of cortisone and corticotropin (ACTH). These agents appeared to have no effect on the complaints.
