Comment on “Photodegradation of sulfathiazole under simulated sunlight: Kinetics, photo-induced structural rearrangement, and antimicrobial activities of photoproducts” by Niu et al. [Water Research 124 2017 576–583]
Comment on “Photodegradation of sulfathiazole under simulated sunlight: Kinetics, photo-induced structural rearrangement, and antimicrobial activities of photoproducts” by Niu et al. [Water Research 124 2017 576–583]
复制标题
Niu 等人对“模拟阳光下磺胺噻唑的光降解：动力学、光诱导结构重排和光产物的抗菌活性”的评论。
DOI：
10.1016/j.watres.2017.12.041
复制
发表时间：
2018
期刊：
影响因子：
12.8
通讯作者：
Blaney, Lee
中科院分区：
文献类型：
--
作者：
Hain, Ethan;Wammer, Kristine H.;Blaney, Lee
最近的努力已经采用抗菌敏感性测定来描述抗生素及其转化产物在各种环境过程中的残留抗菌活性。一些作者使用最低抑菌浓度 (MIC) 评估了这些测定的结果；然而，这种方法有根本性的弱点。为了强调最佳实践，本评论描述了使用剂量反应曲线计算半数抑制浓度 (IC50) 的优点以及生长培养基对磺酰胺类抗生素抗菌活性的潜在影响。
Recent efforts have employed antimicrobial susceptibility assays to describe the residual antimicrobial activity of antibiotics and their transformation products in a variety of environmental processes. Some authors have evaluated the results of these assays using the minimum inhibitory concentration (MIC); however, this approach has fundamental weaknesses. To highlight best practices, this comment describes the advantages of using dose-response curves to calculate the half maximal inhibitory concentration (IC50) and the potential impacts of growth media on the antimicrobial activity of sulfonamide antibiotics.