THE MOLECULAR MECHANISM BY WHICH INSULIN STIMUALTES GLYCOGEN-SYNTHESIS IN MAMMALIAN SKELETAL-MUSCLE
THE MOLECULAR MECHANISM BY WHICH INSULIN STIMUALTES GLYCOGEN-SYNTHESIS IN MAMMALIAN SKELETAL-MUSCLE
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DOI：
10.1038/348302a0
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发表时间：
1990-11-22
期刊：
影响因子：
64.8
通讯作者：
COHEN, P
中科院分区：
文献类型：
--
作者：
DENT, P;LAVOINNE, A;COHEN, P
胰岛素促进一些蛋白质的磷酸化和另一些蛋白质的去磷酸化的能力是矛盾的。一种胰岛素刺激的蛋白激酶被证明可以激活控制糖原代谢的1型蛋白磷酸酶，方法是将其调节亚基在特定的丝氨酸上磷酸化。此外，体内胰岛素刺激该残基的磷酸化。因此，胰岛素增加和减少蛋白质的磷酸化可以通过相同的基本潜在机制来解释。
The ability of insulin to promote the phosphoryl-ation of some proteins and the dephosphorylation of others is paradoxical. An insulin-stimulated protein kinase is shown to activate the type-1 protein phosphatase that controls glycogen metabolism, by phosphorylating its regulatory subunit at a specific serine. Furthermore, the phosphorylation of this residue is stimulated by insulinin vivo. Increased and decreased phosphorylation of proteins by insulin can therefore be explained through the same basic underlying mechanism.